Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 5/20 | 0.40 |
| ▸ | MTNR1B | P49286 | 5/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | PPARG | P37231 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | METAP2 | P50579 | 3/20 | 0.38 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.36 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.35 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.35 |
| ▸ | TUBB | P07437 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1648250 | 0.89 | METAP2 (0.43) | MAPTMETAP2ADORA2AADORA1L3MBTL1 | |
| SCHEMBL18801304 | 0.81 | METAP2 (0.49) | ALDH1A1PPARGLMNAMETAP2L3MBTL1 | |
| SCHEMBL18801277 | 0.81 | CYP2C9 (0.42) | ALDH1A1LMNAMETAP2TUBB4ATUBB | |
| SCHEMBL1649341 | 0.81 | METAP2 (0.47) | ALDH1A1PPARGMETAP2L3MBTL1TUBB4A | |
| SCHEMBL1648096 | 0.80 | METAP2 (0.44) | MTNR1BALDH1A1PPARGLMNAMAPT | |
| SCHEMBL18801318 | 0.80 | METAP2 (0.43) | ALDH1A1LMNAMAPTHSD17B10METAP2 | |
| SCHEMBL1649106 | 0.80 | METAP2 (0.39) | MTNR1AMTNR1BPPARGMETAP2L3MBTL1 | |
| SCHEMBL1648140 | 0.79 | MTNR1A (0.46) | MTNR1AMTNR1BALDH1A1LMNAMAPT | |
| SCHEMBL1648474 | 0.79 | METAP2 (0.38) | ALDH1A1LMNAMAPTHSD17B10METAP2 | |
| SCHEMBL18801336 | 0.79 | LMNA (0.44) | ALDH1A1LMNAMAPTHSD17B10METAP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2486004-B1 | SULPHONE COMPOUNDS FOR USE IN THE TREATMENT OF OBESITY | ZAFGEN INC (US) | 2017-05-03 | — | — | EP | disclosed |