Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP12 | P39900 | 1/20 | 0.40 |
| ▸ | KDM1A | O60341 | 4/20 | 0.39 |
| ▸ | GLRA1 | P23415 | 1/20 | 0.38 |
| ▸ | PTGER1 | P34995 | 2/20 | 0.38 |
| ▸ | PTGER4 | P35408 | 2/20 | 0.38 |
| ▸ | PTGER3 | P43115 | 2/20 | 0.38 |
| ▸ | PTGER2 | P43116 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | ESR1 | P03372 | 1/20 | 0.37 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.37 |
| ▸ | BRD4 | O60885 | 1/20 | 0.37 |
| ▸ | AKR1B10 | O60218 | 2/20 | 0.36 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16032856 | 0.89 | LMNA (0.47) | MMP12KDM1AGLRA1PTGER1PTGER4 | |
| SCHEMBL16096561 | 0.76 | PTPN1 (0.45) | KDM1AGLRA1PTGER1PTGER4PTGER3 | |
| SCHEMBL3176483 | 0.71 | KDM1A (0.50) | KDM1ARAB9AMAOBL3MBTL1 | |
| SCHEMBL2303271 | 0.71 | LMNA (0.50) | GLRA1L3MBTL1LMNA | |
| SCHEMBL114275 | 0.70 | HCAR2 (0.54) | MMP12NPC1RAB9AESR1ESR2 | |
| SCHEMBL27547309 | 0.70 | HCAR2 (0.54) | MMP12NPC1RAB9AESR1ESR2 | |
| SCHEMBL25826288 | 0.70 | ABCB1 (0.50) | — | |
| SCHEMBL3617567 | 0.70 | PTPN1 (0.61) | KDM1APTGER1NPC1BRD4MAOB | |
| SCHEMBL872788 | 0.69 | HCAR2 (0.50) | MMP12NPC1RAB9AESR1ESR2 | |
| SCHEMBL29232860 | 0.69 | TSHR (0.58) | NPC1RAB9AESR1ESR2AKR1B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3114111-B1 | BICYCLIC PYRROLE DERIVATIVES USEFUL AS AGONISTS OF GPR120 | JANSSEN PHARMACEUTICA NV (BE) | 2019-01-09 | — | — | EP | disclosed |
| EP-2970182-B1 | BICYCLIC PYRROLE DERIVATIVES USEFUL AS AGONISTS OF GPR120 | JANSSEN PHARMACEUTICA NV (BE) | 2017-05-03 | — | — | EP | disclosed |