SCHEMBL3617567

SCHEMBL3617567

CC(=O)Oc1ccc(F)c(OCc2ccccc2)c1F

nearest known ligand 0.61

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PTPN1 P18031 1/20 0.61
ALDH1A1 P00352 2/20 0.45
KDM1A O60341 4/20 0.45
CYP4F2 P78329 1/20 0.44
CYP4A11 Q02928 1/20 0.44
BRD4 O60885 2/20 0.43
SMN1; SMN2 Q16637 2/20 0.43
L3MBTL1 Q9Y468 2/20 0.43
NPC1 O15118 1/20 0.43
MAPT P10636 1/20 0.43
CYP2C9 P11712 1/20 0.43
CYP2C19 P33261 1/20 0.43
TDP1 Q9NUW8 1/20 0.43
PTGER1 P34995 1/20 0.42
MRGPRX4 Q96LA9 1/20 0.42
MAOB P27338 1/20 0.42
LMNA P02545 1/20 0.42
HPGD P15428 1/20 0.42
HTT P42858 1/20 0.42
ATM Q13315 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6199847 0.87 PTPN1 (0.63) PTPN1ALDH1A1KDM1ABRD4L3MBTL1
SCHEMBL16096561 0.85 PTPN1 (0.45) PTPN1ALDH1A1KDM1AL3MBTL1NPC1
SCHEMBL18066381 0.85 PTPN1 (0.76) PTPN1ALDH1A1KDM1ACYP4F2CYP4A11
SCHEMBL4841962 0.81 PTPN1 (0.52) PTPN1ALDH1A1KDM1ABRD4SMN1; SMN2
SCHEMBL4846617 0.78 ALDH1A1 (0.54) PTPN1ALDH1A1KDM1ABRD4SMN1; SMN2
SCHEMBL27832255 0.78 KDM1A (0.39) PTPN1KDM1ABRD4NPC1PTGER1
SCHEMBL4840332 0.78 FFAR1 (0.55) PTPN1MRGPRX4MAOB
SCHEMBL13072824 0.77 CYP4F2 (0.43) CYP4F2CYP4A11PTGS2
SCHEMBL28814038 0.77 KDM1A (0.45) PTPN1KDM1ASMN1; SMN2L3MBTL1NPC1
SCHEMBL8565737 0.77 KDM1A (0.55) KDM1ASMN1; SMN2L3MBTL1MAPTCYP2C19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2010134580-A1 METHOD FOR PRODUCING AROMATIC FLUORINE COMPOUND AND NOVEL COMPOUND 静岡県公立大学法人 (JP) 2010-11-25 WO disclosed