SCHEMBL188052

SCHEMBL188052

Fc1cc2cc[nH]c2cc1F

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GPR84 Q9NQS5 1/20 1.00
AHR P35869 7/20 0.58
CSNK2A1 P68400 1/20 0.47
CYP2A6 P11509 3/20 0.46
NR4A2 P43354 2/20 0.46
CMA1 P23946 1/20 0.46
F7 P08709 1/20 0.46
LTA4H P09960 1/20 0.46
F3 P13726 1/20 0.46
TYR P14679 1/20 0.46
USP2 O75604 1/20 0.46
GAA P10253 1/20 0.46
ALOX15 P16050 1/20 0.46
RAD51 Q06609 1/20 0.46
NPSR1 Q6W5P4 1/20 0.46
TRPA1 O75762 1/20 0.42
CA1 P00915 1/20 0.42
CA2 P00918 1/20 0.42
ITGB2 P05107 1/20 0.42
ICAM1 P05362 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1609911 0.87 GPR84 (0.76) GPR84AHRCSNK2A1CYP2A6NR4A2
SCHEMBL30593539 0.82 GPR84 (0.69) GPR84AHRCSNK2A1CYP2A6NR4A2
SCHEMBL579164 0.82 GPR84 (0.69) GPR84AHRCSNK2A1CYP2A6NR4A2
SCHEMBL30370306 0.82 GPR84 (0.69) GPR84AHRCSNK2A1CYP2A6NR4A2
SCHEMBL1401662 0.82 GPR84 (0.69) GPR84AHRCSNK2A1CYP2A6NR4A2
SCHEMBL31040068 0.82 GPR84 (0.69) GPR84AHRCSNK2A1CYP2A6NR4A2
SCHEMBL394578 0.82 GPR84 (0.69) GPR84AHRCSNK2A1CYP2A6NR4A2
SCHEMBL187774 0.82 GPR84 (0.69) GPR84AHRCSNK2A1CYP2A6NR4A2
SCHEMBL1565699 0.82 GPR84 (0.69) GPR84AHRCSNK2A1CYP2A6NR4A2
SCHEMBL29507011 0.82 GPR84 (0.69) GPR84AHRCSNK2A1CYP2A6NR4A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 354 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4526426-A2 METHODS FOR PRODUCING MONOTERPENE INDOLE ALKALOIDS Danmarks Tekniske Universitet (DK) 2025-03-26 EP claimed
EP-3356387-B1 ANTIMICROBIAL POLYMYXIN DERIVATIVE COMPOUNDS UNIV MONASH (AU) 2024-06-26 EP claimed
WO-2023222879-A2 METHODS FOR PRODUCING MONOTERPENE INDOLE ALKALOIDS DANMARKS TEKNISKE UNIVERSITET (DK) 2023-11-23 WO claimed
CN-114805664-B Bionic modified marine antifouling resin material, and preparation method and application thereof 江苏苏博特新材料股份有限公司 2023-04-14 CN claimed
CN-114805664-A Bionic modified marine antifouling resin material, and preparation method and application thereof 江苏苏博特新材料股份有限公司 2022-07-29 CN claimed
CN-114292582-B Hyperbranched coating suitable for marine concrete, and preparation method and application thereof 江苏苏博特新材料股份有限公司 2022-07-12 CN claimed
CN-114292582-A Hyperbranched coating suitable for marine concrete, and preparation method and application thereof 江苏苏博特新材料股份有限公司 2022-04-08 CN claimed
CN-108350034-B Antimicrobial polymyxin derived compounds 莫纳什大学 2022-03-11 CN claimed
CN-104073045-A Application of halogenated indole and derivatives thereof as marine antifouling agent YANTAI INST COASTAL ZONE RES CAS 2014-10-01 CN claimed
CN-122079853-A N-substituted indoles and other heterocyclic compounds for the treatment of brain diseases 2026-05-26 CN disclosed
US-12612424-B2 HPK1 inhibitors and uses thereof REGOR PHARMACEUTICALS, INC. (US) 2026-04-28 US disclosed
US-20250354108-A1 METHODS FOR PRODUCING MONOTERPENE INDOLE ALKALOIDS UNIV DANMARKS TEKNISKE (DK) 2025-11-20 US disclosed
EP-4638441-A1 GLYCINE DERIVATIVES WITH P2X4 RECEPTOR-BLOCKING ACTIVITY AS DIAGNOSTICS AND FOR THE TREATMENT OF PAIN, INFLAMMATION, CANCER, AND OTHER P2X4 RECEPTOR-RELATED DISEASES Rheinische Friedrich-Wilhelms-Universität Bonn (DE) 2025-10-29 EP disclosed
US-12448368-B2 Indole compounds as androgen receptor modulators NIDO BIOSCIENCES, INC. (US) 2025-10-21 US disclosed
EP-1109813-A1 PYRROLOINDOLES, PYRIDOINDOLES AND AZEPINOINDOLES AS 5-HT2C AGONISTS VERNALIS RESEARCH LIMITED (GB) 2001-06-27 EP disclosed
US-6166040-A Indole compounds ELI LILLY AND COMPANY LIMITED (GB) 2000-12-26 US disclosed
WO-2000012510-A1 PYRROLOINDOLES, PYRIDOINDOLES AND AZEPINOINDOLES AS 5-HT2C AGONISTS VERNALIS RESEARCH LIMITED (GB) 2000-03-09 WO disclosed
EP-0963983-A1 Indol-2-ones as serotonin modulators ELI LILLY AND COMPANY LIMITED (GB) 1999-12-15 EP disclosed
US-5494928-A FOR CENTRAL NERVOUS SYSTEM DISORDERS, BLOCKING SEROTONIN RECEPTORS, ANTIDEPRESSANTS HOFFMANN-LA ROCHE INC. (US) 1996-02-27 US disclosed
EP-0655440-A2 1-Aminoethylindoles F. HOFFMANN-LA ROCHE AG (CH) 1995-05-31 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12612424-B2 HPK1 inhibitors and uses thereof NEK11, NEK1, CSNK1A1 GPR84 1636/4885AHR 1168/4885CSNK2A1 27/4885
US-12448368-B2 Indole compounds as androgen receptor modulators AR, FSHR, ADRB3 GPR84 181/4885AHR 174/4885CSNK2A1 1276/4885
US-20250354108-A1 METHODS FOR PRODUCING MONOTERPENE INDOLE ALKALOIDS INMT, KARS1, MIA3 GPR84 3005/4885AHR 361/4885CSNK2A1 3129/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.