Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 10/20 | 0.54 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.46 |
| ▸ | EGFR | P00533 | 1/20 | 0.34 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.34 |
| ▸ | MPL | P40238 | 5/20 | 0.33 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.32 |
| ▸ | CDK2 | P24941 | 1/20 | 0.32 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.32 |
| ▸ | GSK3A | P49840 | 1/20 | 0.32 |
| ▸ | CDK9 | P50750 | 1/20 | 0.32 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.32 |
| ▸ | TAOK1 | Q7L7X3 | 1/20 | 0.32 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.32 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18797824 | 0.72 | MKNK1 (0.54) | MKNK1MKNK2EGFRERBB2MPL | |
| SCHEMBL18786784 | 0.72 | MKNK1 (0.69) | MKNK1MKNK2MPL | |
| SCHEMBL18786622 | 0.70 | MKNK1 (0.59) | MKNK1MKNK2 | |
| SCHEMBL18786706 | 0.70 | MKNK1 (1.00) | MKNK1MKNK2 | |
| SCHEMBL20863344 | 0.67 | ALDH1A1 (0.33) | — | |
| SCHEMBL22238836 | 0.67 | PDE3B (0.41) | — | |
| SCHEMBL18815025 | 0.67 | MKNK1 (0.54) | MKNK1MKNK2EGFRERBB2 | |
| SCHEMBL18797844 | 0.67 | MKNK1 (0.59) | MKNK1MKNK2EGFRERBB2GSK3A | |
| SCHEMBL18814767 | 0.67 | MKNK1 (0.53) | MKNK1MKNK2EGFRERBB2 | |
| SCHEMBL18815026 | 0.66 | MKNK1 (0.56) | MKNK1MKNK2EGFRERBB2MPL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108602805-A | Isoindoline, azaisoindoline, indenone and the dihydro azepine indone inhibitor of MNK1 and MNK2 | 效应治疗股份有限公司 | 2018-09-28 | — | — | CN | disclosed |