Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 2/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | MMP1 | P03956 | 3/20 | 0.50 |
| ▸ | MMP3 | P08254 | 3/20 | 0.50 |
| ▸ | MMP9 | P14780 | 2/20 | 0.49 |
| ▸ | GNPAT | O15228 | 1/20 | 0.49 |
| ▸ | MMP2 | P08253 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | THRB | P10828 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | ERAP2 | Q6P179 | 2/20 | 0.48 |
| ▸ | LNPEP | Q9UIQ6 | 2/20 | 0.48 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.48 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | CPA1 | P15085 | 1/20 | 0.47 |
| ▸ | CPA2 | P48052 | 1/20 | 0.47 |
| ▸ | CPA4 | Q9UI42 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22695988 | 0.88 | MMP2 (0.56) | MMP1MMP3MMP9GNPATMMP2 | |
| SCHEMBL16856622 | 0.88 | MMP2 (0.56) | MMP1MMP3MMP9GNPATMMP2 | |
| SCHEMBL23128421 | 0.86 | GNPAT (0.52) | MMP1MMP3MMP9GNPATMMP2 | |
| SCHEMBL22695740 | 0.86 | GNPAT (0.54) | MMP1MMP3MMP9GNPATMMP2 | |
| SCHEMBL15948101 | 0.86 | GNPAT (0.54) | MMP1MMP3MMP9GNPATMMP2 | |
| SCHEMBL22600860 | 0.85 | GNPAT (0.53) | MMP1MMP3MMP9GNPATMMP2 | |
| SCHEMBL21503819 | 0.84 | GNPAT (0.50) | MMP1MMP3MMP9GNPATMMP2 | |
| SCHEMBL22268858 | 0.84 | OPRK1 (0.52) | MMP1MMP3MMP9GNPATMMP2 | |
| SCHEMBL22133739 | 0.84 | GNPAT (0.52) | MMP1MMP3MMP9GNPATMMP2 | |
| SCHEMBL20034953 | 0.84 | MMP1 (0.53) | MMP1MMP3MMP9GNPATMMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022115451-A1 | MCL-1 INHIBITOR ANTIBODY-DRUG CONJUGATES AND METHODS OF USE | NOVARTIS AG (CH) | 2022-06-02 | — | — | WO | disclosed |
| WO-2020236825-A2 | MCL-1 INHIBITOR ANTIBODY-DRUG CONJUGATES AND METHODS OF USE | NOVARTIS AG (CH) | 2020-11-26 | — | — | WO | disclosed |
| WO-2017072662-A1 | ANTIBODY CONJUGATES COMPRISING TOLL-LIKE RECEPTOR AGONIST | NOVARTIS AG (CH) | 2017-05-04 | — | — | WO | disclosed |