Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR4A2 | P43354 | 4/20 | 0.71 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.71 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.71 |
| ▸ | SRD5A2 | P31213 | 4/20 | 0.70 |
| ▸ | TSHR | P16473 | 1/20 | 0.68 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.68 |
| ▸ | MEN1 | O00255 | 1/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.65 |
| ▸ | RXRA | P19793 | 2/20 | 0.63 |
| ▸ | RXRB | P28702 | 2/20 | 0.63 |
| ▸ | RXRG | P48443 | 2/20 | 0.63 |
| ▸ | PLA2G4B | P0C869 | 1/20 | 0.62 |
| ▸ | MAOB | P27338 | 1/20 | 0.58 |
| ▸ | MRGPRX4 | Q96LA9 | 3/20 | 0.58 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.58 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.58 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6342568 | 0.91 | NR4A2 (0.71) | NR4A2NR4A1NR4A3SRD5A2TSHR | |
| SCHEMBL1221359 | 0.89 | NR4A2 (0.90) | NR4A2NR4A1NR4A3SRD5A2SMN1; SMN2 | |
| SCHEMBL19490438 | 0.89 | NR4A2 (0.58) | NR4A2NR4A1NR4A3SRD5A2TSHR | |
| SCHEMBL1123461 | 0.88 | NR4A2 (0.81) | NR4A2NR4A1NR4A3SRD5A2TSHR | |
| SCHEMBL16886110 | 0.86 | MAOB (0.70) | NR4A2MEN1KMT2AMAOBFFAR1 | |
| SCHEMBL228477 | 0.84 | NR4A2 (1.00) | NR4A2NR4A1NR4A3SRD5A2SMN1; SMN2 | |
| SCHEMBL4059143 | 0.84 | NR4A2 (1.00) | NR4A2NR4A1NR4A3SRD5A2SMN1; SMN2 | |
| SCHEMBL6830467 | 0.84 | NR4A2 (1.00) | NR4A2NR4A1NR4A3SRD5A2SMN1; SMN2 | |
| SCHEMBL19490437 | 0.84 | L3MBTL1 (0.56) | NR4A2NR4A1NR4A3SRD5A2SMN1; SMN2 | |
| SCHEMBL2708209 | 0.84 | SRD5A2 (0.71) | SRD5A2RXRARXRBRXRGAKR1C3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9796716-B2 | Selective inhibitors of Tec and Src protein kinase families | PHARMASCIENCE, INC. (CA) | 2017-10-24 | — | — | US | disclosed |
| US-20110106241-A1 | COMPOSITIONS AND METHODS FOR INHIBITING SPHINGOSINE KINASE | UNIVERSITY OF VIRGINIA PATENT FOUNDATION | 2011-05-05 | — | — | US | disclosed |
| US-20110106241-A1 | COMPOSITIONS AND METHODS FOR INHIBITING SPHINGOSINE KINASE | UNIVERSITY OF VIRGINIA PATENT FOUNDATION | 2011-05-05 | — | — | US | disclosed |
| WO-2009146112-A1 | COMPOSITIONS AND METHODS FOR INHIBITING SPHINGOSINE KINASE | UNIVERSITY OF VIRGINIA PATENT FOUNDATION (US) | 2009-12-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110106241-A1 | COMPOSITIONS AND METHODS FOR INHIBITING SPHINGOSINE KINASE | SPHK2, SPHK1, S1PR2 | NR4A2 4188/4885NR4A1 4655/4885NR4A3 4217/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.