Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR4A2 | P43354 | 5/20 | 0.81 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.81 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.81 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.76 |
| ▸ | TSHR | P16473 | 1/20 | 0.76 |
| ▸ | SRD5A2 | P31213 | 2/20 | 0.74 |
| ▸ | RXRA | P19793 | 2/20 | 0.71 |
| ▸ | RXRB | P28702 | 2/20 | 0.71 |
| ▸ | RXRG | P48443 | 2/20 | 0.71 |
| ▸ | PLA2G4B | P0C869 | 1/20 | 0.70 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.68 |
| ▸ | MRGPRX4 | Q96LA9 | 5/20 | 0.65 |
| ▸ | MEN1 | O00255 | 1/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.64 |
| ▸ | PTPRC | P08575 | 1/20 | 0.63 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.63 |
| ▸ | TP53 | P04637 | 1/20 | 0.62 |
| ▸ | PKM | P14618 | 1/20 | 0.62 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.62 |
| ▸ | RAB9A | P51151 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL228477 | 0.90 | NR4A2 (1.00) | NR4A2NR4A1NR4A3SMN1; SMN2SRD5A2 | |
| SCHEMBL6830467 | 0.90 | NR4A2 (1.00) | NR4A2NR4A1NR4A3SMN1; SMN2SRD5A2 | |
| SCHEMBL4059143 | 0.90 | NR4A2 (1.00) | NR4A2NR4A1NR4A3SMN1; SMN2SRD5A2 | |
| SCHEMBL1122713 | 0.89 | NR4A2 (0.94) | NR4A2NR4A1NR4A3SMN1; SMN2TSHR | |
| SCHEMBL11603274 | 0.89 | NR4A2 (0.96) | NR4A2NR4A1NR4A3SMN1; SMN2SRD5A2 | |
| Hydrochloric Acid SCHEMBL8544438 | 0.89 | NR4A2 (0.96) | NR4A2NR4A1NR4A3SMN1; SMN2SRD5A2 | |
| SCHEMBL11273693 | 0.89 | NR4A2 (0.96) | NR4A2NR4A1NR4A3SMN1; SMN2SRD5A2 | |
| SCHEMBL11603952 | 0.89 | NR4A2 (0.96) | NR4A2NR4A1NR4A3SMN1; SMN2SRD5A2 | |
| SCHEMBL3649253 | 0.88 | MRGPRX4 (0.76) | NR4A2NR4A1NR4A3SMN1; SMN2TSHR | |
| SCHEMBL1881853 | 0.88 | NR4A2 (0.71) | NR4A2NR4A1NR4A3SMN1; SMN2TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9908849-B2 | Imidamide sphingosine kinase inhibitors | UNIVERSITY OF VIRGINIA PATENT FOUNDATION (US) | 2018-03-06 | — | — | US | disclosed |
| US-20170166525-A1 | IMIDAMIDE SPHINGOSINE KINASE INHIBITORS | UNIVERSITY OF VIRGINIA | 2017-06-15 | — | — | US | disclosed |
| US-9421177-B2 | Imidamide sphingosine kinase inhibitors | UNIVERSITY OF VIRGINIA PATENT FOUNDATION (US) | 2016-08-23 | — | — | US | disclosed |
| US-20120214858-A1 | IMIDAMIDE SPHINGOSINE KINASE INHIBITORS | UNIVERSITY OF VIRGINIA PATENT FOUNDATION (US) | 2012-08-23 | — | — | US | disclosed |
| WO-2011020116-A1 | IMIDAMIDE SPHINGOSINE KINASE INHIBITORS | UNIVERSITY OF VIRGINIA PATENT FOUNDATION (US) | 2011-02-17 | — | — | WO | disclosed |
| EP-1644321-B1 | NEW BENZAMIDES AS PPATY MODULATORS | S A L V A T LAB SA (ES) | 2011-02-09 | — | — | EP | disclosed |
| CN-1835914-A | New benzamides as PPAR[upsilon] modulators | S A L V A T LAB SA (ES) | 2006-09-20 | — | — | CN | disclosed |
| US-20060160894-A1 | Benzamides as ppar modulators | LABORATORIOS S.A.L.V.A.T.,S.A. (ES) | 2006-07-20 | — | — | US | disclosed |
| EP-1644321-A2 | NEW BENZAMIDES AS PPATY MODULATORS | LABORATORIOS S.A.L.V.A.T., S.A. (ES) | 2006-04-12 | — | — | EP | disclosed |
| WO-2004110983-A2 | NEW BENZAMIDES AS PPARϒ MODULATORS | LABORATORIOS S.A.L.V.A.T., S.A. (ES) | 2004-12-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060160894-A1 | Benzamides as ppar modulators | PPARD, PPARA, PPARG | NR4A2 66/4885NR4A1 46/4885NR4A3 88/4885 |
| US-20120214858-A1 | IMIDAMIDE SPHINGOSINE KINASE INHIBITORS | SPHK2, SPHK1, S1PR2 | NR4A2 2540/4885NR4A1 3626/4885NR4A3 3073/4885 |
| US-20170166525-A1 | IMIDAMIDE SPHINGOSINE KINASE INHIBITORS | SPHK2, SPHK1, S1PR2 | NR4A2 2540/4885NR4A1 3626/4885NR4A3 3073/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.