Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 7/20 | 0.57 |
| ▸ | ATR | Q13535 | 1/20 | 0.46 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.43 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.43 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.43 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.43 |
| ▸ | LSS | P48449 | 1/20 | 0.42 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.42 |
| ▸ | PDE3B | Q13370 | 3/20 | 0.41 |
| ▸ | PDE3A | Q14432 | 3/20 | 0.41 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.41 |
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.41 |
| ▸ | PDE2A | O00408 | 2/20 | 0.40 |
| ▸ | TNKS | O95271 | 1/20 | 0.40 |
| ▸ | ACHE | P22303 | 1/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18824690 | 0.96 | ATM (0.52) | ATMATRADORA3ADORA2AADORA2B | |
| SCHEMBL18844674 | 0.81 | ATM (0.64) | ATMATRPDE3BPDE3AP2RY12 | |
| SCHEMBL18824834 | 0.79 | ATM (0.46) | ATMATRADORA3ADORA2AADORA2B | |
| SCHEMBL18641851 | 0.79 | ATM (0.62) | ATMPIK3CA | |
| SCHEMBL18824924 | 0.78 | ATM (0.59) | ATMATRPDE3BPDE3AP2RY12 | |
| SCHEMBL18824692 | 0.77 | ATM (0.48) | ATMATRADORA3ADORA2AADORA2B | |
| SCHEMBL18641733 | 0.77 | ATM (0.42) | ATMATRPIK3CA | |
| SCHEMBL18641856 | 0.75 | ATM (0.61) | ATMATRPIK3CA | |
| SCHEMBL18824583 | 0.75 | ATM (0.54) | ATMATRADORA3ADORA2AADORA2B | |
| SCHEMBL18641743 | 0.73 | TYMS (0.40) | ATMPDE3BPDE3APDE2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3371183-A1 | IMIDAZO[4,5-C]QUINOLIN-2-ONE COMPOUNDS AND THEIR USE IN TREATING CANCER | Astrazeneca AB (SE) | 2018-09-12 | — | — | EP | disclosed |
| WO-2017076895-A1 | IMIDAZO[4,5-C]QUINOLIN-2-ONE COMPOUNDS AND THEIR USE IN TREATING CANCER | ASTRAZENECA AB (SE) | 2017-05-11 | — | — | WO | disclosed |