SCHEMBL18825258

SCHEMBL18825258

O=C(CN1C(=O)CCC1=O)c1ccc2ccccc2c1

nearest known ligand 0.63

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 4/20 0.63
RAB9A P51151 3/20 0.63
CDYL Q9Y232 6/20 0.62
CBX7 O95931 5/20 0.62
CDYL2 Q8N8U2 4/20 0.62
CDY1; CDY1B Q9Y6F8 4/20 0.62
KDM4E B2RXH2 3/20 0.57
LMNA P02545 2/20 0.57
GAA P10253 1/20 0.57
GFER P55789 1/20 0.57
PTPN1 P18031 1/20 0.54
HPGD P15428 2/20 0.50
ALDH1A1 P00352 2/20 0.50
ACHE P22303 1/20 0.50
CES2 O00748 1/20 0.49
CES1 P23141 1/20 0.49
CA12 O43570 1/20 0.48
CA1 P00915 1/20 0.48
CA2 P00918 1/20 0.48
CA9 Q16790 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29236557 0.81 GSK3B (0.63) SMN1; SMN2RAB9ACDYLCBX7CDYL2
SCHEMBL18825267 0.80 SMN1; SMN2 (0.81) SMN1; SMN2RAB9AKDM4EHPGDALDH1A1
SCHEMBL5846697 0.78 SMN1; SMN2 (0.77) SMN1; SMN2RAB9AKDM4ELMNAHPGD
SCHEMBL11577852 0.76 BCHE (0.56) SMN1; SMN2RAB9AKDM4ELMNAGAA
SCHEMBL4866787 0.75 ACHE (0.67) SMN1; SMN2KDM4EPTPN1HPGDALDH1A1
Hydrochloric Acid SCHEMBL3842041 0.74 ACHE (0.66) KDM4EPTPN1ALDH1A1ACHENPC1
SCHEMBL1974978 0.74 PTPN1 (0.71) SMN1; SMN2RAB9AKDM4ELMNAPTPN1
SCHEMBL29489791 0.74 PTPN1 (0.71) SMN1; SMN2RAB9AKDM4ELMNAPTPN1
SCHEMBL18825265 0.73 SMN1; SMN2 (0.66) SMN1; SMN2RAB9AHPGDALDH1A1NPC1
SCHEMBL18825263 0.73 RAB9A (0.66) SMN1; SMN2RAB9AKDM4ELMNAHPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2017077550-A1 A METAL FREE PROCESS FOR THE PREPARATION OF ALPHA-SUBSTITUTED CARBONYL COMPOUNDS FROM ALKENES COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) 2017-05-11 WO claimed
WO-2017077550-A1 A METAL FREE PROCESS FOR THE PREPARATION OF ALPHA-SUBSTITUTED CARBONYL COMPOUNDS FROM ALKENES COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) 2017-05-11 WO disclosed