Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.77 |
| ▸ | RAB9A | P51151 | 2/20 | 0.77 |
| ▸ | GSK3B | P49841 | 3/20 | 0.54 |
| ▸ | GSK3A | P49840 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.47 |
| ▸ | TSHR | P16473 | 4/20 | 0.46 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.46 |
| ▸ | SRD5A2 | P31213 | 2/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.44 |
| ▸ | TP53 | P04637 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | STAT1 | P42224 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18825267 | 0.93 | SMN1; SMN2 (0.81) | SMN1; SMN2RAB9AGSK3BGSK3AKMT2A | |
| SCHEMBL18825263 | 0.79 | RAB9A (0.66) | SMN1; SMN2RAB9AGSK3BKMT2AALDH1A1 | |
| SCHEMBL18825265 | 0.79 | SMN1; SMN2 (0.66) | SMN1; SMN2RAB9AGSK3BKMT2AALDH1A1 | |
| SCHEMBL18825258 | 0.78 | SMN1; SMN2 (0.63) | SMN1; SMN2RAB9AKMT2AALDH1A1KDM4E | |
| SCHEMBL12640291 | 0.75 | RAB9A (0.60) | SMN1; SMN2RAB9AKMT2AALDH1A1TSHR | |
| SCHEMBL18825272 | 0.75 | NPC1 (0.64) | SMN1; SMN2RAB9AGSK3BKMT2AALDH1A1 | |
| SCHEMBL18825274 | 0.74 | RAB9A (0.59) | SMN1; SMN2RAB9AGSK3B | |
| SCHEMBL18825271 | 0.74 | TSHR (0.60) | SMN1; SMN2RAB9AKMT2AALDH1A1TSHR | |
| SCHEMBL26744028 | 0.74 | RAB9A (0.59) | SMN1; SMN2RAB9AGSK3BGSK3AKMT2A | |
| SCHEMBL17336171 | 0.74 | SMN1; SMN2 (0.55) | SMN1; SMN2RAB9AGSK3BGSK3AKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7151112-B1 | Pharmaceutical uses and synthesis of nicotinamides | UCB SA (GB) | 2006-12-19 | — | — | US | disclosed |
| US-6777432-B1 | TREATING A SUBJECT HAVING AN INFLAMMATORY DISORDER ALLEVIATED BY THE INHIBITION OF GRO- ALPHA CYTOKINES | DARWIN MOLECULAR CORPORATION | 2004-08-17 | — | — | US | disclosed |