Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 3/20 | 0.42 |
| ▸ | HPGDS | O60760 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.41 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.41 |
| ▸ | SYK | P43405 | 1/20 | 0.41 |
| ▸ | PDE1A | P54750 | 2/20 | 0.38 |
| ▸ | PDE1B | Q01064 | 2/20 | 0.38 |
| ▸ | PDE1C | Q14123 | 2/20 | 0.38 |
| ▸ | MAPK6 | Q16659 | 4/20 | 0.38 |
| ▸ | GPR6 | P46095 | 2/20 | 0.37 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.37 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.37 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.36 |
| ▸ | P2RX2 | Q9UBL9 | 1/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.36 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18830059 | 0.94 | MAPK1 (0.43) | MKNK1HPGDSMAPK1MAPK3SYK | |
| SCHEMBL18830128 | 0.92 | MAPK6 (0.38) | MKNK1HPGDSMAPK1MAPK3SYK | |
| SCHEMBL18830090 | 0.86 | SYK (0.44) | SYKMAPK6 | |
| SCHEMBL18830136 | 0.86 | SYK (0.42) | SYKMAPK6 | |
| SCHEMBL18830257 | 0.85 | MEN1 (0.43) | SYKMAPK6 | |
| SCHEMBL18830434 | 0.84 | MAPK6 (0.52) | SYKMAPK6MAPK8 | |
| SCHEMBL18830094 | 0.83 | CDK1 (0.46) | MKNK1HPGDSMAPK6MAPK8 | |
| SCHEMBL18830031 | 0.83 | MAPK6 (0.42) | HPGDSSYKMAPK6MAPK8MAPK9 | |
| SCHEMBL18830600 | 0.83 | DRD2 (0.40) | MAPK1MAPK6 | |
| SCHEMBL18830424 | 0.82 | CDK1 (0.46) | MAPK6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2964649-B1 | TRIAZOLO[4,5-D]PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF DISEASES SUCH AS CANCER | MERCK PATENT GMBH (DE) | 2017-05-10 | — | — | EP | disclosed |