Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK6 | Q16659 | 6/20 | 0.51 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | DRD3 | P35462 | 1/20 | 0.40 |
| ▸ | PSEN1 | P49768 | 8/20 | 0.40 |
| ▸ | PSEN2 | P49810 | 8/20 | 0.40 |
| ▸ | APH1B | Q8WW43 | 8/20 | 0.40 |
| ▸ | NCSTN | Q92542 | 8/20 | 0.40 |
| ▸ | APH1A | Q96BI3 | 8/20 | 0.40 |
| ▸ | PSENEN | Q9NZ42 | 8/20 | 0.40 |
| ▸ | F10 | P00742 | 1/20 | 0.38 |
| ▸ | EHMT2 | Q96KQ7 | 1/20 | 0.38 |
| ▸ | GPR6 | P46095 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18830424 | 0.86 | CDK1 (0.46) | MAPK6 | |
| SCHEMBL18830090 | 0.84 | SYK (0.44) | MAPK6 | |
| SCHEMBL18830136 | 0.84 | SYK (0.42) | MAPK6 | |
| SCHEMBL18830059 | 0.83 | MAPK1 (0.43) | MAPK6 | |
| SCHEMBL18830257 | 0.83 | MEN1 (0.43) | MAPK6 | |
| SCHEMBL18830573 | 0.83 | CDK1 (0.40) | MAPK6 | |
| SCHEMBL18830600 | 0.83 | DRD2 (0.40) | MAPK6DRD2DRD3 | |
| SCHEMBL18830434 | 0.82 | MAPK6 (0.52) | MAPK6 | |
| SCHEMBL18830415 | 0.82 | CDK1 (0.40) | MAPK6DRD2DRD3 | |
| SCHEMBL18830031 | 0.81 | MAPK6 (0.42) | MAPK6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2964649-B1 | TRIAZOLO[4,5-D]PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF DISEASES SUCH AS CANCER | MERCK PATENT GMBH (DE) | 2017-05-10 | — | — | EP | disclosed |