Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LPAR1 | Q92633 | 6/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | F10 | P00742 | 2/20 | 0.42 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.40 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.40 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.40 |
| ▸ | PDE4A | P27815 | 1/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.40 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.40 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.39 |
| ▸ | NOX1 | Q9Y5S8 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1561434 | 0.88 | LPAR1 (0.61) | LPAR1GAAF10SMPD1HDAC1 | |
| SCHEMBL18832655 | 0.88 | LPAR1 (0.53) | LPAR1SMPD1HDAC1HDAC8HDAC6 | |
| SCHEMBL18832654 | 0.88 | LPAR1 (0.63) | LPAR1SMPD1HDAC1HDAC8HDAC6 | |
| SCHEMBL1560217 | 0.87 | LPAR1 (0.54) | LPAR1GAAF10SMPD1HDAC1 | |
| SCHEMBL18832670 | 0.83 | LPAR1 (0.49) | LPAR1GAASMPD1HDAC1HDAC8 | |
| SCHEMBL18832658 | 0.83 | LPAR1 (0.58) | LPAR1NPC1RAB9ASCN9A | |
| SCHEMBL18832678 | 0.82 | LPAR1 (0.63) | LPAR1SMPD1HDAC1HDAC8HDAC6 | |
| SCHEMBL18832674 | 0.81 | LPAR1 (0.60) | LPAR1SMPD1HDAC1HDAC8HDAC6 | |
| SCHEMBL18832661 | 0.81 | LPAR1 (0.60) | LPAR1GAA | |
| SCHEMBL18832660 | 0.81 | LPAR1 (0.59) | LPAR1SMPD1HDAC1HDAC8HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2303270-B1 | ACYLAMINO-SUBSTITUTED FUSED CYCLOPENTANECARBOXYLIC ACID DERIVATIVES AND THEIR USE AS PHARMACEUTICALS | SANOFI SA (FR) | 2017-05-17 | — | — | EP | claimed |