Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 11/20 | 0.49 |
| ▸ | TP53 | P04637 | 3/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.47 |
| ▸ | PKM | P14618 | 2/20 | 0.47 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 4/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | STAT6 | P42226 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.44 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18834584 | 0.76 | TRPC5 (0.50) | MAPTTP53 | |
| SCHEMBL19375348 | 0.73 | TRPC5 (0.47) | MAPTALDH1A1PKMHIF1AGAA | |
| SCHEMBL19375320 | 0.73 | ALDH1A1 (0.39) | MAPTTP53ALDH1A1PKMGAA | |
| SCHEMBL19375583 | 0.73 | MAPT (0.37) | MAPTTP53ALDH1A1LMNAMEN1 | |
| SCHEMBL18834071 | 0.69 | KMT2A (0.44) | MAPTALDH1A1GAAMEN1KMT2A | |
| SCHEMBL28015900 | 0.69 | HPGD (0.52) | MAPTTP53ALDH1A1GAAHTT | |
| SCHEMBL16028263 | 0.68 | HPGD (0.62) | MAPTTP53ALDH1A1HTTLMNA | |
| SCHEMBL3940708 | 0.67 | HPGD (0.64) | ALDH1A1PKMLMNAMEN1KMT2A | |
| SCHEMBL18834990 | 0.67 | ALDH1A1 (0.48) | MAPTTP53ALDH1A1HTTLMNA | |
| SCHEMBL19956915 | 0.66 | CHEK1 (0.59) | ALDH1A1LMNAMEN1KMT2ARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2970303-B1 | SUBSTITUTED XANTHINES AND METHODS OF USE THEREOF | HYDRA BIOSCIENCES INC (US) | 2017-05-10 | — | — | EP | disclosed |