Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPC5 | Q9UL62 | 2/20 | 0.56 |
| ▸ | TRPC1 | P48995 | 1/20 | 0.56 |
| ▸ | TRPC4 | Q9UBN4 | 1/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | P2RX3 | P56373 | 5/20 | 0.52 |
| ▸ | PCSK9 | Q8NBP7 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | THRB | P10828 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16076242 | 0.86 | TRPC5 (0.63) | TRPC5TRPC1TRPC4KDM4EALDH1A1 | |
| SCHEMBL16028274 | 0.85 | TRPC5 (0.74) | TRPC5TRPC1TRPC4KDM4EALDH1A1 | |
| SCHEMBL19505332 | 0.85 | TRPC5 (0.58) | TRPC5TRPC1TRPC4KDM4EALDH1A1 | |
| SCHEMBL16028515 | 0.81 | P2RX3 (0.56) | TRPC5TRPC1TRPC4P2RX3 | |
| SCHEMBL19498710 | 0.79 | P2RX3 (0.56) | TRPC5TRPC1TRPC4KDM4EALDH1A1 | |
| SCHEMBL16028242 | 0.78 | TRPC5 (0.88) | TRPC5TRPC1TRPC4ALDH1A1PCSK9 | |
| SCHEMBL19375458 | 0.78 | TRPC5 (0.71) | TRPC5TRPC1TRPC4ALDH1A1PCSK9 | |
| SCHEMBL18834886 | 0.75 | TRPC5 (0.68) | TRPC5TRPC1TRPC4ALDH1A1MAPK1 | |
| SCHEMBL16028375 | 0.74 | TRPC5 (0.74) | TRPC5TRPC1TRPC4ALDH1A1MAPK1 | |
| SCHEMBL19498711 | 0.74 | P2RX3 (0.61) | TRPC5TRPC1TRPC4KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2970303-B1 | SUBSTITUTED XANTHINES AND METHODS OF USE THEREOF | HYDRA BIOSCIENCES INC (US) | 2017-05-10 | — | — | EP | disclosed |