Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 6/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.53 |
| ▸ | TSHR | P16473 | 3/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 4/20 | 0.51 |
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.46 |
| ▸ | TRPC4 | Q9UBN4 | 1/20 | 0.46 |
| ▸ | TRPC5 | Q9UL62 | 1/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21316308 | 0.89 | TRPC5 (0.60) | ATMMAPTALDH1A1NPSR1TSHR | |
| SCHEMBL18021083 | 0.83 | MAPT (0.58) | ATMMAPTALDH1A1NPSR1TSHR | |
| SCHEMBL16076170 | 0.82 | TSHR (0.70) | ATMMAPTALDH1A1NPSR1TSHR | |
| SCHEMBL19375261 | 0.81 | TSHR (0.66) | MAPTALDH1A1NPSR1TSHRMAPK1 | |
| SCHEMBL16028784 | 0.79 | TRPC5 (0.64) | ATMMAPTALDH1A1NPSR1TSHR | |
| SCHEMBL16028537 | 0.78 | TRPC5 (0.63) | ATMMAPTALDH1A1NPSR1TSHR | |
| SCHEMBL28371761 | 0.78 | MAPT (0.70) | ATMMAPTALDH1A1NPSR1TSHR | |
| SCHEMBL16076222 | 0.78 | TRPC5 (0.60) | ATMMAPTALDH1A1NPSR1TSHR | |
| SCHEMBL20432512 | 0.78 | TRPC4 (0.60) | ATMMAPTALDH1A1NPSR1TSHR | |
| SCHEMBL28377891 | 0.78 | TRPC5 (0.55) | ATMMAPTALDH1A1NPSR1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2970303-B9 | SUBSTITUTED XANTHINES AND METHODS OF USE THEREOF | HYDRA BIOSCIENCES INC (US) | 2017-09-20 | — | — | EP | disclosed |
| EP-2970303-B1 | SUBSTITUTED XANTHINES AND METHODS OF USE THEREOF | HYDRA BIOSCIENCES INC (US) | 2017-05-10 | — | — | EP | disclosed |