Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 5/20 | 0.66 |
| ▸ | POLB | P06746 | 1/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.55 |
| ▸ | LMNA | P02545 | 5/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.49 |
| ▸ | CASP1 | P29466 | 1/20 | 0.49 |
| ▸ | CASP7 | P55210 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.47 |
| ▸ | TRPC4 | Q9UBN4 | 1/20 | 0.47 |
| ▸ | TRPC5 | Q9UL62 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16027799 | 0.92 | TSHR (0.62) | TSHRPOLBALDH1A1KDM4ELMNA | |
| SCHEMBL16363971 | 0.85 | ALDH1A1 (0.54) | TSHRPOLBALDH1A1KDM4ELMNA | |
| SCHEMBL29103734 | 0.82 | TSHR (0.61) | TSHRPOLBALDH1A1KDM4ELMNA | |
| SCHEMBL18021083 | 0.81 | MAPT (0.58) | TSHRPOLBALDH1A1LMNANPSR1 | |
| SCHEMBL19374800 | 0.81 | TSHR (0.81) | TSHRPOLBALDH1A1KDM4ELMNA | |
| SCHEMBL18834149 | 0.81 | ATM (0.54) | TSHRPOLBALDH1A1LMNANPSR1 | |
| SCHEMBL18989610 | 0.80 | MAPT (0.57) | TSHRPOLBALDH1A1KDM4ELMNA | |
| SCHEMBL16028290 | 0.78 | TRPC5 (0.60) | TSHRPOLBALDH1A1LMNANPSR1 | |
| SCHEMBL16076170 | 0.78 | TSHR (0.70) | TSHRPOLBALDH1A1KDM4ELMNA | |
| SCHEMBL16028784 | 0.77 | TRPC5 (0.64) | TSHRPOLBALDH1A1LMNANPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2970303-B9 | SUBSTITUTED XANTHINES AND METHODS OF USE THEREOF | HYDRA BIOSCIENCES INC (US) | 2017-09-20 | — | — | EP | disclosed |