Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPC4 | Q9UBN4 | 2/20 | 0.34 |
| ▸ | TRPC5 | Q9UL62 | 2/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | P2RX3 | P56373 | 16/20 | 0.34 |
| ▸ | TRPC1 | P48995 | 1/20 | 0.34 |
| ▸ | MDM2 | Q00987 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19375125 | 0.80 | TRPC4 (0.45) | TRPC4TRPC5KCNH2P2RX3TRPC1 | |
| SCHEMBL18835291 | 0.76 | COMT (0.34) | TRPC5P2RX3MDM2 | |
| SCHEMBL16028229 | 0.75 | TRPC5 (0.62) | TRPC4TRPC5KCNH2TRPC1 | |
| SCHEMBL18835283 | 0.70 | TRPC5 (0.46) | TRPC4TRPC5KCNH2P2RX3TRPC1 | |
| SCHEMBL16028337 | 0.69 | TRPC5 (0.69) | TRPC4TRPC5KCNH2TRPC1 | |
| SCHEMBL18834346 | 0.68 | TRPC5 (0.46) | TRPC4TRPC5KCNH2TRPC1 | |
| SCHEMBL19375468 | 0.68 | P2RX3 (0.43) | P2RX3 | |
| SCHEMBL16028336 | 0.68 | TRPC4 (0.61) | TRPC4TRPC5KCNH2TRPC1 | |
| SCHEMBL16364304 | 0.68 | TRPC5 (0.48) | TRPC4TRPC5KCNH2P2RX3TRPC1 | |
| SCHEMBL21345008 | 0.67 | ALDH1A1 (0.38) | TRPC4TRPC5KCNH2TRPC1MDM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2970303-B1 | SUBSTITUTED XANTHINES AND METHODS OF USE THEREOF | HYDRA BIOSCIENCES INC (US) | 2017-05-10 | — | — | EP | disclosed |