Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.36 |
| ▸ | PDE5A | O76074 | 9/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | TRPC1 | P48995 | 1/20 | 0.31 |
| ▸ | TRPC4 | Q9UBN4 | 1/20 | 0.31 |
| ▸ | TRPC5 | Q9UL62 | 1/20 | 0.31 |
| ▸ | MAOA | P21397 | 1/20 | 0.31 |
| ▸ | MAOB | P27338 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 2/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.30 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | PTBP1 | P26599 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19375603 | 0.83 | TRPC5 (0.38) | ADORA3PDE5ATRPC1TRPC4TRPC5 | |
| SCHEMBL21316262 | 0.81 | P2RX3 (0.41) | PDE5AALDH1A1HPGDTRPC4TRPC5 | |
| SCHEMBL21499654 | 0.81 | P2RX3 (0.40) | PDE5ATRPC4TRPC5 | |
| SCHEMBL21499715 | 0.81 | P2RX3 (0.36) | PDE5ATSHRTRPC1TRPC4TRPC5 | |
| SCHEMBL18834435 | 0.80 | MAPT (0.39) | ADORA3PDE5ATSHRALDH1A1HPGD | |
| SCHEMBL21499680 | 0.80 | P2RX3 (0.39) | ADORA3TSHRALDH1A1HPGDTRPC1 | |
| SCHEMBL19505418 | 0.79 | PDE5A (0.42) | ADORA3PDE5ATSHRALDH1A1HPGD | |
| SCHEMBL19374881 | 0.79 | P2RX3 (0.44) | PDE5ATRPC4TRPC5 | |
| SCHEMBL19505572 | 0.79 | TRPC4 (0.47) | ADORA3TRPC1TRPC4TRPC5 | |
| SCHEMBL18835341 | 0.78 | TRPC4 (0.41) | ADORA3PDE5ATSHRALDH1A1TRPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2970303-B3 | SUBSTITUTED XANTHINES AND METHODS OF USE THEREOF | HYDRA BIOSCIENCES INC (US) | 2018-08-01 | — | — | EP | disclosed |
| EP-2970303-B1 | SUBSTITUTED XANTHINES AND METHODS OF USE THEREOF | HYDRA BIOSCIENCES INC (US) | 2017-05-10 | — | — | EP | disclosed |