Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPC5 | Q9UL62 | 4/20 | 0.38 |
| ▸ | TRPC1 | P48995 | 1/20 | 0.38 |
| ▸ | TRPC4 | Q9UBN4 | 1/20 | 0.38 |
| ▸ | DPP4 | P27487 | 1/20 | 0.36 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.35 |
| ▸ | PDE5A | O76074 | 2/20 | 0.34 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.34 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.34 |
| ▸ | HCRTR1 | O43613 | 6/20 | 0.34 |
| ▸ | HCRTR2 | O43614 | 6/20 | 0.34 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18834435 | 0.88 | MAPT (0.39) | TRPC5TRPC4ADORA3PDE5AMAPT | |
| SCHEMBL19375600 | 0.85 | P2RX3 (0.34) | TRPC5TRPC1TRPC4PDE5A | |
| SCHEMBL18833918 | 0.84 | P2RX3 (0.35) | TRPC5TRPC1TRPC4ADORA3PDE5A | |
| SCHEMBL21499680 | 0.83 | P2RX3 (0.39) | TRPC5TRPC1TRPC4ADORA3CYP3A4 | |
| SCHEMBL19505503 | 0.83 | TRPC4 (0.39) | TRPC5TRPC1TRPC4MAPT | |
| SCHEMBL19375436 | 0.83 | P2RX7 (0.35) | TRPC5TRPC1TRPC4ADORA3PDE5A | |
| SCHEMBL18834254 | 0.83 | TRPC4 (0.40) | TRPC5TRPC1TRPC4PDE5ACYP3A4 | |
| SCHEMBL18835145 | 0.83 | ADORA3 (0.36) | TRPC5TRPC1TRPC4ADORA3PDE5A | |
| SCHEMBL21499678 | 0.82 | TRPC5 (0.48) | TRPC5TRPC1TRPC4HCRTR1HCRTR2 | |
| SCHEMBL21499669 | 0.82 | TRPC5 (0.49) | TRPC5TRPC1TRPC4HCRTR1HCRTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2970303-B9 | SUBSTITUTED XANTHINES AND METHODS OF USE THEREOF | HYDRA BIOSCIENCES INC (US) | 2017-09-20 | — | — | EP | disclosed |