Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPC4 | Q9UBN4 | 2/20 | 0.42 |
| ▸ | TRPC5 | Q9UL62 | 2/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.40 |
| ▸ | TRPC1 | P48995 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16068298 | 0.83 | TRPC5 (0.60) | TRPC4TRPC5KCNH2TRPC1ALDH1A1 | |
| SCHEMBL18835260 | 0.81 | TRPC4 (0.51) | TRPC4TRPC5KCNH2HSD17B10TRPC1 | |
| SCHEMBL19375424 | 0.77 | TRPC4 (0.41) | TRPC4TRPC5KCNH2TRPC1SMN1; SMN2 | |
| SCHEMBL16076223 | 0.76 | MAPT (0.53) | TRPC4TRPC5KCNH2TRPC1ALDH1A1 | |
| SCHEMBL19375225 | 0.75 | TP53 (0.41) | TRPC4TRPC5KCNH2TRPC1ALDH1A1 | |
| SCHEMBL18834207 | 0.73 | TRPC5 (0.75) | TRPC4TRPC5KCNH2TRPC1ALDH1A1 | |
| SCHEMBL16028393 | 0.73 | TRPC5 (0.66) | TRPC4TRPC5KCNH2TRPC1ALDH1A1 | |
| SCHEMBL18833941 | 0.72 | TRPC4 (0.47) | TRPC4TRPC5KCNH2TRPC1ALDH1A1 | |
| SCHEMBL18834872 | 0.72 | TRPC5 (0.65) | TRPC4TRPC5KCNH2TRPC1ALDH1A1 | |
| SCHEMBL16028784 | 0.71 | TRPC5 (0.64) | TRPC4TRPC5KCNH2TRPC1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2970303-B9 | SUBSTITUTED XANTHINES AND METHODS OF USE THEREOF | HYDRA BIOSCIENCES INC (US) | 2017-09-20 | — | — | EP | disclosed |