Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 11/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | MYC | P01106 | 3/20 | 0.41 |
| ▸ | PLK1 | P53350 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | GFER | P55789 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23147392 | 0.87 | NOTUM (0.58) | NOTUMALDH1A1MYCTP53 | |
| SCHEMBL19377711 | 0.85 | ALOX12 (0.45) | NOTUMALDH1A1KMT2AMYC | |
| SCHEMBL19377692 | 0.83 | MAPT (0.59) | ALDH1A1KMT2AGAATP53 | |
| SCHEMBL18836571 | 0.82 | NOTUM (0.59) | NOTUMALDH1A1MYCGAA | |
| SCHEMBL19377726 | 0.81 | NOTUM (0.59) | NOTUMALDH1A1KMT2APLK1TP53 | |
| SCHEMBL29288027 | 0.81 | KMT2A (0.48) | NOTUMALDH1A1KMT2AGAATP53 | |
| SCHEMBL19377806 | 0.80 | POLB (0.45) | NOTUMALDH1A1KMT2AMYCGAA | |
| SCHEMBL29626100 | 0.80 | POLB (0.45) | NOTUMALDH1A1KMT2AMYCGAA | |
| SCHEMBL19398173 | 0.79 | KMT2A (0.43) | NOTUMALDH1A1KMT2ATP53 | |
| SCHEMBL19377679 | 0.78 | NOTUM (0.51) | NOTUMALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 39 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260042765-A1 | PYRROLOTRIAZINE COMPOUNDS AS TAM INHIBITORS | INCYTE CORP (US) | 2026-02-12 | — | — | US | disclosed |
| US-12415809-B2 | Pyrrolotriazine compounds as tam inhibitors | INCYTE CORPORATION (US) | 2025-09-16 | — | — | US | disclosed |
| CN-114456175-B | Pyrrolotriazine compounds as TAM inhibitors | 因赛特公司 | 2024-09-03 | — | — | CN | disclosed |
| CN-114456176-B | Pyrrolotriazine compounds as TAM inhibitors | 因赛特公司 | 2024-08-30 | — | — | CN | disclosed |
| US-20240124463-A1 | PYRROLOTRIAZINE COMPOUNDS AS TAM INHIBITORS | INCYTE CORPORATION | 2024-04-18 | — | — | US | disclosed |
| EP-4321513-A2 | PYRROLOTRIAZINE COMPOUNDS AS TAM INHIBITORS | Incyte Corporation (US) | 2024-02-14 | — | — | EP | disclosed |
| EP-3436461-B1 | PYRROLOTRIAZINE COMPOUNDS AS TAM INHIBITORS | INCYTE CORP (US) | 2023-11-01 | — | — | EP | disclosed |
| EP-3436461-B1 | PYRROLOTRIAZINE COMPOUNDS AS TAM INHIBITORS | INCYTE CORP (US) | 2023-11-01 | — | — | EP | disclosed |
| US-11591338-B2 | Pyrrolotriazine compounds as TAM inhibitors | INCYTE CORPORATION (US) | 2023-02-28 | — | — | US | disclosed |
| CN-114456176-A | Pyrrolotriazine compounds as TAM inhibitors | 因赛特公司 | 2022-05-10 | — | — | CN | disclosed |
| US-20170275290-A1 | PYRROLOTRIAZINE COMPOUNDS AS TAM INHIBITORS | INCYTE CORPORATION | 2017-09-28 | — | — | US | disclosed |
| US-20170275290-A1 | PYRROLOTRIAZINE COMPOUNDS AS TAM INHIBITORS | INCYTE CORPORATION | 2017-09-28 | — | — | US | disclosed |
| US-20170275290-A1 | PYRROLOTRIAZINE COMPOUNDS AS TAM INHIBITORS | INCYTE CORPORATION | 2017-09-28 | — | — | US | disclosed |
| US-9738656-B2 | Pyranodipyridine compound | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2017-08-22 | — | — | US | disclosed |
| US-9738656-B2 | Pyranodipyridine compound | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2017-08-22 | — | — | US | disclosed |
| US-9738656-B2 | Pyranodipyridine compound | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2017-08-22 | — | — | US | disclosed |
| US-20170137436-A1 | Pyranodipyridine Compound | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2017-05-18 | — | — | US | disclosed |
| US-20170137436-A1 | Pyranodipyridine Compound | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2017-05-18 | — | — | US | disclosed |
| US-20170137436-A1 | Pyranodipyridine Compound | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2017-05-18 | — | — | US | disclosed |
| WO-2017082288-A1 | PYRANODIPYRIDINE COMPOUND | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 2017-05-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20260042765-A1 | PYRROLOTRIAZINE COMPOUNDS AS TAM INHIBITORS | MAP2K2, TTK, MAP2K5 | NOTUM 1928/4885ALDH1A1 2069/4885KMT2A 806/4885 |
| US-20170275290-A1 | PYRROLOTRIAZINE COMPOUNDS AS TAM INHIBITORS | MERTK, MAP3K15, MAP3K5 | NOTUM 4398/4885ALDH1A1 2279/4885KMT2A 640/4885 |
| US-12415809-B2 | Pyrrolotriazine compounds as tam inhibitors | MERTK, MAP3K15, MAP3K5 | NOTUM 4398/4885ALDH1A1 2279/4885KMT2A 640/4885 |
| US-20170137436-A1 | Pyranodipyridine Compound | DPYD, CYP2D6, XDH | NOTUM 3338/4885ALDH1A1 656/4885KMT2A 2450/4885 |
| US-11591338-B2 | Pyrrolotriazine compounds as TAM inhibitors | MERTK, MAP3K15, MAP3K5 | NOTUM 4398/4885ALDH1A1 2279/4885KMT2A 640/4885 |
| US-20240124463-A1 | PYRROLOTRIAZINE COMPOUNDS AS TAM INHIBITORS | MERTK, MAP3K15, MAP3K5 | NOTUM 4398/4885ALDH1A1 2279/4885KMT2A 640/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.