Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | MYC | P01106 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | TYK2 | P29597 | 1/20 | 0.39 |
| ▸ | SLC11A2 | P49281 | 2/20 | 0.39 |
| ▸ | DPP4 | P27487 | 1/20 | 0.39 |
| ▸ | ALKBH3 | Q96Q83 | 1/20 | 0.39 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.38 |
| ▸ | ALKBH2 | Q6NS38 | 1/20 | 0.38 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.38 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19377806 | 1.00 | POLB (0.45) | POLBGAATSHRMYCSMN1; SMN2 | |
| SCHEMBL29626186 | 0.88 | POLB (0.44) | POLBGAATSHRSMN1; SMN2ALDH1A1 | |
| SCHEMBL28966273 | 0.84 | NOTUM (0.44) | POLBGAATSHRMYCSMN1; SMN2 | |
| SCHEMBL31051678 | 0.84 | NPC1 (0.51) | POLBGAATSHRSMN1; SMN2ALDH1A1 | |
| SCHEMBL19377928 | 0.84 | NPC1 (0.51) | POLBGAATSHRSMN1; SMN2ALDH1A1 | |
| SCHEMBL25220685 | 0.81 | NOTUM (0.41) | GAAMYCALDH1A1KDM4EMAPK14 | |
| SCHEMBL18836673 | 0.80 | NOTUM (0.55) | GAAMYCALDH1A1KMT2ANOTUM | |
| SCHEMBL28966268 | 0.80 | KMT2A (0.44) | GAATSHRMYCALDH1A1KDM4E | |
| SCHEMBL18836571 | 0.76 | NOTUM (0.59) | GAAMYCSMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL19377711 | 0.75 | ALOX12 (0.45) | POLBMYCSMN1; SMN2ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114456175-B | Pyrrolotriazine compounds as TAM inhibitors | 因赛特公司 | 2024-09-03 | — | — | CN | disclosed |
| CN-114456176-B | Pyrrolotriazine compounds as TAM inhibitors | 因赛特公司 | 2024-08-30 | — | — | CN | disclosed |
| EP-3436461-B1 | PYRROLOTRIAZINE COMPOUNDS AS TAM INHIBITORS | INCYTE CORP (US) | 2023-11-01 | — | — | EP | disclosed |
| CN-114456175-A | Pyrrolotriazine compounds as TAM inhibitors | 因赛特公司 | 2022-05-10 | — | — | CN | disclosed |
| CN-114456176-A | Pyrrolotriazine compounds as TAM inhibitors | 因赛特公司 | 2022-05-10 | — | — | CN | disclosed |