Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 6/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | LTA4H | P09960 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18837979 | 0.84 | DRD2 (0.40) | LMNAALDH1A1CYP3A4CYP2C19DRD2 | |
| SCHEMBL14375263 | 0.83 | ALDH1A1 (0.49) | ALDH1A1HRH3DRD2LTA4H | |
| SCHEMBL31010060 | 0.79 | DRD2 (0.47) | KDM4EALDH1A1HRH3HRH4CYP2C19 | |
| SCHEMBL12449661 | 0.75 | LMNA (0.46) | LMNAKDM4EALDH1A1L3MBTL1CYP3A4 | |
| SCHEMBL12393 | 0.75 | LMNA (0.46) | LMNAKDM4EALDH1A1L3MBTL1CYP3A4 | |
| SCHEMBL15014645 | 0.74 | LMNA (0.55) | LMNAKDM4EALDH1A1HRH3L3MBTL1 | |
| SCHEMBL12518832 | 0.72 | CYP2D6 (0.47) | LMNAKDM4EALDH1A1HRH3HRH4 | |
| SCHEMBL19850990 | 0.70 | LMNA (0.53) | LMNAKDM4EALDH1A1HRH3HRH4 | |
| SCHEMBL1201919 | 0.70 | LMNA (0.53) | LMNAKDM4EALDH1A1HRH3HRH4 | |
| SCHEMBL19674414 | 0.69 | DRD2 (0.45) | LMNAALDH1A1HRH3DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2917185-B1 | SULFOXIMINE SUBSTITUTED QUINAZOLINES FOR PHARMACEUTICAL COMPOSITIONS | EVOTEC INT GMBH (DE) | 2017-05-10 | — | — | EP | disclosed |