Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 1/20 | 0.46 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.45 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.45 |
| ▸ | JAK2 | O60674 | 1/20 | 0.45 |
| ▸ | JAK1 | P23458 | 1/20 | 0.45 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.45 |
| ▸ | KDM1A | O60341 | 2/20 | 0.44 |
| ▸ | STS | P08842 | 1/20 | 0.44 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.44 |
| ▸ | ACHE | P22303 | 1/20 | 0.44 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.43 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | TACR1 | P25103 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18838380 | 0.98 | NAMPT (0.46) | NAMPTKEAP1NFE2L2JAK2JAK1 | |
| SCHEMBL18838507 | 0.89 | KEAP1 (0.49) | NAMPTKEAP1NFE2L2GPR119KDM1A | |
| SCHEMBL16914195 | 0.89 | LMNA (0.48) | NAMPTGPR119STSLMNA | |
| SCHEMBL18838379 | 0.87 | STS (0.51) | NAMPTKEAP1NFE2L2GPR119KDM1A | |
| SCHEMBL15601289 | 0.84 | KEAP1 (0.46) | NAMPTKEAP1NFE2L2JAK2JAK1 | |
| SCHEMBL18838335 | 0.82 | USP30 (0.53) | NAMPTGPR119KDM1AUSP30KDM4E | |
| SCHEMBL30989041 | 0.81 | NPFFR1 (0.49) | NAMPTJAK2JAK1GPR119STS | |
| Trifluoroacetic Acid SCHEMBL15577382 | 0.80 | KEAP1 (0.42) | NAMPTKEAP1NFE2L2GPR119KDM1A | |
| SCHEMBL16914492 | 0.79 | ALDH1A1 (0.44) | GPR119STSLMNA | |
| SCHEMBL16914194 | 0.78 | ALDH1A1 (0.51) | NAMPTGPR119STSLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3340988-A1 | ION CHANNEL INHIBITORY COMPOUNDS, PHARMACEUTICAL FORMULATIONS AND USES | Afasci, Inc. (US) | 2018-07-04 | — | — | EP | disclosed |
| WO-2017083867-A1 | ION CHANNEL INHIBITORY COMPOUNDS, PHARMACEUTICAL FORMULATIONS AND USES | AFASCI, INC. (US) | 2017-05-18 | — | — | WO | disclosed |