Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | PDE4B | Q07343 | 5/20 | 0.43 |
| ▸ | PDE4A | P27815 | 4/20 | 0.43 |
| ▸ | PDE4C | Q08493 | 4/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 4/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | PIM1 | P11309 | 1/20 | 0.39 |
| ▸ | ESR1 | P03372 | 1/20 | 0.38 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.38 |
| ▸ | ERN1 | O75460 | 1/20 | 0.38 |
| ▸ | EP300 | Q09472 | 1/20 | 0.36 |
| ▸ | KCNB1 | Q14721 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18838215 | 0.87 | KDM4E (0.43) | HTTLMNAPDE4BPDE4APDE4C | |
| SCHEMBL18838172 | 0.84 | TUBB4A (0.42) | HTTLMNAPDE4BPDE4APDE4C | |
| SCHEMBL18838817 | 0.83 | KDM4E (0.40) | HTTLMNAPDE4BPDE4APDE4C | |
| SCHEMBL18838238 | 0.82 | MAPT (0.48) | HTTKDM4ETP53GAAMAPT | |
| SCHEMBL18838181 | 0.81 | HTT (0.44) | HTTLMNAPDE4BPDE4APDE4C | |
| SCHEMBL18838239 | 0.80 | PDE4B (0.40) | HTTLMNAPDE4BPDE4APDE4C | |
| SCHEMBL9812714 | 0.75 | KDM4E (0.64) | HTTLMNAPDE4BPDE4APDE4C | |
| SCHEMBL18838816 | 0.75 | ALOX5 (0.45) | PDE4BPDE4APDE4CPDE4DGAA | |
| SCHEMBL18871343 | 0.75 | PKM (0.41) | HTTLMNAPDE4BPDE4APDE4C | |
| SCHEMBL18838191 | 0.75 | PIM1 (0.45) | PDE4BPDE4APDE4CPDE4DKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190202774-A1 | BIARYL COMPOUNDS AS ANTIMICROBIAL AND CHEMOTHERAPEUTIC AGENTS | WILLIAM MARSH RICE UNIVERSITY (US) | 2019-07-04 | — | — | US | disclosed |
| US-20190202774-A1 | BIARYL COMPOUNDS AS ANTIMICROBIAL AND CHEMOTHERAPEUTIC AGENTS | WILLIAM MARSH RICE UNIVERSITY (US) | 2019-07-04 | — | — | US | disclosed |
| WO-2017083702-A1 | BIARYL COMPOUNDS AS ANTIMICROBIAL AND CHEMOTHERAPEUTIC AGENTS | WILLIAM MARSH RICE UNIVERSITY (US) | 2017-05-18 | — | — | WO | disclosed |
| WO-2017083719-A1 | TRANSITION METAL FREE METHODS OF SYNTHESIS OF BIARYL COMPOUNDS | WILLIAM MARSH RICE UNIVERSITY (US) | 2017-05-18 | — | — | WO | disclosed |
| WO-2017083702-A1 | BIARYL COMPOUNDS AS ANTIMICROBIAL AND CHEMOTHERAPEUTIC AGENTS | WILLIAM MARSH RICE UNIVERSITY (US) | 2017-05-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190202774-A1 | BIARYL COMPOUNDS AS ANTIMICROBIAL AND CHEMOTHERAPEUTIC AGENTS | MCL1, BCL2, BCL2L2 | HTT 4231/4885LMNA 3145/4885PDE4B 3664/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.