SCHEMBL188441

SCHEMBL188441

CCCC[C@](N)(C(=O)O)C(F)(F)F

nearest known ligand 0.41

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
FDPS P14324 3/20 0.41
CES2 O00748 3/20 0.38
FAAH O00519 8/20 0.38
CES1 P23141 5/20 0.36
MEN1 O00255 2/20 0.36
CYP1A2 P05177 2/20 0.36
KMT2A Q03164 2/20 0.36
HSD17B10 Q99714 1/20 0.36
ALDH1A1 P00352 1/20 0.35
THRB P10828 1/20 0.35
LPAR1 Q92633 1/20 0.34
LPAR3 Q9UBY5 1/20 0.34
SMPD1 P17405 1/20 0.34
ODC1 P11926 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL188440 1.00 FDPS (0.41) FDPSCES2FAAHCES1MEN1
SCHEMBL5704613 1.00 FDPS (0.41) FDPSCES2FAAHCES1MEN1
SCHEMBL21199502 0.87 MEN1 (0.38) FDPSCES2FAAHCES1MEN1
SCHEMBL5704692 0.87 MEN1 (0.38) FDPSCES2FAAHCES1MEN1
SCHEMBL5704688 0.87 MEN1 (0.38) FDPSCES2FAAHCES1MEN1
SCHEMBL28817817 0.85 FDPS (0.42) FDPSMEN1CYP1A2KMT2AALDH1A1
SCHEMBL4812447 0.81 ODC1 (0.53) FDPSMEN1CYP1A2KMT2AALDH1A1
SCHEMBL4812451 0.81 ODC1 (0.53) FDPSMEN1CYP1A2KMT2AALDH1A1
SCHEMBL4812444 0.81 ODC1 (0.53) FDPSMEN1CYP1A2KMT2AALDH1A1
SCHEMBL7203565 0.79 ODC1 (0.47) FDPSMEN1CYP1A2KMT2AALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 46 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20030194378-A1 Novel aerosol formulation containing a polar fluorinated molecule ASTRAZENECA AB (SE) 2003-10-16 US claimed
EP-1303258-A1 NOVEL AEROSOL FORMULATION CONTAINING A POLAR FLUORINATED MOLECULE AstraZeneca AB (SE) 2003-04-23 EP claimed
WO-2002003958-A1 NOVEL AEROSOL FORMULATION CONTAINING A POLAR FLUORINATED MOLECULE ASTRAZENECA AB (SE) 2002-01-17 WO claimed
EP-4687443-A1 METHOD FOR FUNCTIONALISING A SOLID SUBSTRATE WITH A PEPTIDE CONJUGATE Genepep (FR) 2026-02-11 EP disclosed
WO-2024208878-A1 METHOD FOR FUNCTIONALISING A SOLID SUBSTRATE WITH A PEPTIDE CONJUGATE GENEPEP (FR) 2024-10-10 WO disclosed
US-20230414702-A1 COMPOUNDS AND PHARMACEUTICAL USE THEREOF IN THE TREATMENT OF CANCER PEPKON SAS (FR) 2023-12-28 US disclosed
US-11759496-B2 Compounds and pharmaceutical use thereof in the treatment of cancer Karoyan, Philippe (FR) 2023-09-19 US disclosed
EP-3454879-B1 NEW COMPOUNDS AND PHARMACEUTICAL USE THEREOF IN THE TREATMENT OF CANCER INST NAT SANTE RECH MED (FR) 2021-12-22 EP disclosed
US-20190144501-A1 NEW COMPOUNDS AND PHARMACEUTICAL USE THEREOF IN THE TREATMENT OF CANCER PEPKON SAS (FR) 2019-05-16 US disclosed
EP-3454879-A1 NEW COMPOUNDS AND PHARMACEUTICAL USE THEREOF IN THE TREATMENT OF CANCER INSERM (Institut National de la Santé et de la Recherche Médicale) (FR) 2019-03-20 EP disclosed
EP-3220957-B1 CONJUGATED MOLECULES COMPRISING A PEPTIDE DERIVED FROM THE CD4 RECEPTOR COUPLED TO AN ANIONIC POLYPEPTIDE FOR THE TREATMENT OF AIDS PASTEUR INSTITUT (FR) 2018-11-07 EP disclosed
WO-2010023295-A1 PIPECOLIC LINKER AND ITS USE FOR CHEMISTRY ON SOLID SUPPORT CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) (FR) 2010-03-04 WO disclosed
US-20080249030-A1 Age Inhibitors CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) 2008-10-09 US disclosed
EP-1863832-A1 AGE INHIBITORS Pharmamens (FR) 2007-12-12 EP disclosed
WO-2006103274-A9 AGE INHIBITORS PHARMAMENS (FR) 2007-01-18 WO disclosed
EP-1303258-B1 NOVEL AEROSOL FORMULATION CONTAINING A POLAR FLUORINATED MOLECULE ASTRAZENECA AB (SE) 2006-10-11 EP disclosed
WO-2006103274-A1 AGE INHIBITORS PHARMAMENS (FR) 2006-10-05 WO disclosed
US-20030194378-A1 Novel aerosol formulation containing a polar fluorinated molecule ASTRAZENECA AB (SE) 2003-10-16 US disclosed
EP-1303258-A1 NOVEL AEROSOL FORMULATION CONTAINING A POLAR FLUORINATED MOLECULE AstraZeneca AB (SE) 2003-04-23 EP disclosed
WO-2002003958-A1 NOVEL AEROSOL FORMULATION CONTAINING A POLAR FLUORINATED MOLECULE ASTRAZENECA AB (SE) 2002-01-17 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20190144501-A1 NEW COMPOUNDS AND PHARMACEUTICAL USE THEREOF IN THE TREATMENT OF CANCER VIP, RNASE1, ABCB11 FDPS 1413/4885CES2 4508/4885FAAH 4466/4885
US-11759496-B2 Compounds and pharmaceutical use thereof in the treatment of cancer VIP, RNASE1, ABCB11 FDPS 1221/4885CES2 4240/4885FAAH 4510/4885
US-20230414702-A1 COMPOUNDS AND PHARMACEUTICAL USE THEREOF IN THE TREATMENT OF CANCER VIP, RNASE1, ABCB11 FDPS 1221/4885CES2 4240/4885FAAH 4510/4885
US-20080249030-A1 Age Inhibitors CFH, XPA, XPNPEP1 FDPS 2807/4885CES2 371/4885FAAH 105/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.