Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | S1PR2 | O95136 | 9/20 | 0.37 |
| ▸ | S1PR1 | P21453 | 9/20 | 0.37 |
| ▸ | S1PR3 | Q99500 | 9/20 | 0.37 |
| ▸ | S1PR4 | O95977 | 8/20 | 0.37 |
| ▸ | DNM1 | Q05193 | 2/20 | 0.37 |
| ▸ | ADH1B | P00325 | 1/20 | 0.36 |
| ▸ | ADH1C | P00326 | 1/20 | 0.36 |
| ▸ | ADH1A | P07327 | 1/20 | 0.36 |
| ▸ | ADH4 | P08319 | 1/20 | 0.36 |
| ▸ | ADH7 | P40394 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.36 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13976256 | 0.94 | EPHX1 (0.48) | EPHX1LMNAS1PR2S1PR1S1PR3 | |
| SCHEMBL18871732 | 0.89 | EPHX1 (0.43) | EPHX1 | |
| SCHEMBL13976194 | 0.86 | TSHR (0.46) | EPHX1LMNAS1PR2S1PR1S1PR3 | |
| SCHEMBL15786189 | 0.86 | TSHR (0.46) | EPHX1LMNAS1PR2S1PR1S1PR3 | |
| SCHEMBL13976197 | 0.86 | TSHR (0.46) | EPHX1LMNAS1PR2S1PR1S1PR3 | |
| SCHEMBL28935954 | 0.86 | TSHR (0.46) | EPHX1LMNAS1PR2S1PR1S1PR3 | |
| SCHEMBL15786641 | 0.86 | TSHR (0.46) | EPHX1LMNAS1PR2S1PR1S1PR3 | |
| SCHEMBL19890567 | 0.86 | DNM1 (0.46) | EPHX1LMNADNM1ADH1BADH1C | |
| SCHEMBL22765977 | 0.86 | EPHX1 (0.52) | EPHX1LMNADNM1ADH1BADH1C | |
| SCHEMBL8200683 | 0.86 | EPHX1 (0.52) | EPHX1LMNADNM1ADH1BADH1C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170129881-A1 | TRPM8 ANTAGONISTS | DOMPÉ FARMACEUTICI S.P.A. (IT) | 2017-05-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170129881-A1 | TRPM8 ANTAGONISTS | TRPM8, TRPM7, TRPM5 | EPHX1 2709/4885LMNA 4208/4885S1PR2 848/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.