Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 5/20 | 0.68 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.60 |
| ▸ | NPC1 | O15118 | 6/20 | 0.60 |
| ▸ | RAB9A | P51151 | 5/20 | 0.60 |
| ▸ | GAA | P10253 | 1/20 | 0.60 |
| ▸ | MAPT | P10636 | 3/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.53 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.53 |
| ▸ | RELA | Q04206 | 1/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | THRB | P10828 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.51 |
| ▸ | KDR | P35968 | 2/20 | 0.51 |
| ▸ | SENP5 | Q96HI0 | 1/20 | 0.50 |
| ▸ | SENP2 | Q9HC62 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15697561 | 0.88 | HDAC1 (0.74) | HDAC1SMN1; SMN2NPC1RAB9AMAPT | |
| SCHEMBL15697580 | 0.82 | HDAC1 (0.82) | HDAC1SMN1; SMN2NPC1RAB9AMAPT | |
| SCHEMBL3056527 | 0.82 | MAPT (0.49) | HDAC1SMN1; SMN2NPC1RAB9AMAPT | |
| SCHEMBL1886609 | 0.81 | HDAC1 (1.00) | HDAC1PDGFRBKDRSENP5SENP2 | |
| SCHEMBL16395811 | 0.80 | PTPN2 (0.47) | HDAC1NPC1RAB9AGAAMAPT | |
| SCHEMBL19433643 | 0.80 | LMNA (0.48) | HDAC1SMN1; SMN2NPC1RAB9AGAA | |
| SCHEMBL24601427 | 0.79 | MAPT (0.53) | HDAC1SMN1; SMN2NPC1RAB9AGAA | |
| SCHEMBL13709530 | 0.78 | HDAC1 (0.74) | HDAC1SMN1; SMN2NPC1RAB9AALDH1A1 | |
| SCHEMBL23712812 | 0.77 | TERT (0.49) | HDAC1SMN1; SMN2NPC1RAB9AGAA | |
| SCHEMBL16396158 | 0.77 | MAPT (0.58) | HDAC1GAAMAPTALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7935724-B2 | Thiophene and benzothiophene hydroxamic acid derivatives | MERCK HDAC RESEARCH, LLC (US) | 2011-05-03 | — | — | US | disclosed |
| US-20070213392-A1 | Thiophene and Benzothiophene Hydroxamic Acid Derivatives | MERCK HDAC RESEARCH, LLC | 2007-09-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070213392-A1 | Thiophene and Benzothiophene Hydroxamic Acid Derivatives | BRDT, TXN, TXNRD2 | HDAC1 9/4885SMN1; SMN2 1394/4885NPC1 3817/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.