Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 5/20 | 0.40 |
| ▸ | GLA | P06280 | 3/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.38 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 3/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.37 |
| ▸ | AKT1 | P31749 | 1/20 | 0.36 |
| ▸ | AKT2 | P31751 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | HPGD | P15428 | 3/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | CASP1 | P29466 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1934058 | 0.80 | GAA (0.47) | GAAKDM4EPOLBRAB9AGLA | |
| SCHEMBL18855535 | 0.73 | DRD1 (0.31) | — | |
| SCHEMBL18855751 | 0.71 | SMN1; SMN2 (0.32) | SMN1; SMN2 | |
| SCHEMBL24797975 | 0.70 | ELANE (0.47) | GAAKDM4ERAB9AGLACYP1A2 | |
| SCHEMBL10730203 | 0.70 | GAA (0.61) | GAAKDM4EPOLBRAB9ACYP1A2 | |
| Bromide SCHEMBL11083368 | 0.69 | GAA (0.60) | GAAKDM4EPOLBRAB9ACYP1A2 | |
| SCHEMBL871014 | 0.67 | KDM4E (0.69) | GAAKDM4EPOLBRAB9AGLA | |
| SCHEMBL11369182 | 0.66 | GAA (0.52) | GAAKDM4EPOLBRAB9ACYP1A2 | |
| SCHEMBL15176026 | 0.65 | KDM4E (0.62) | GAAKDM4EPOLBRAB9AGLA | |
| SCHEMBL101291 | 0.64 | GAA (1.00) | GAAKDM4EPOLBRAB9ACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3950692-A1 | NOVEL TRICYCLIC COMPOUNDS | AbbVie Inc. (US) | 2022-02-09 | — | — | EP | disclosed |
| EP-2506716-B1 | NOVEL TRICYCLIC COMPOUNDS | ABBVIE INC (US) | 2017-05-17 | — | — | EP | disclosed |