SCHEMBL18856426

SCHEMBL18856426

C=CC(C=C)Cc1ccc(F)cc1

nearest known ligand 0.45

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
TRPA1 O75762 2/20 0.45
IDO1 P14902 3/20 0.42
LOXL2 Q9Y4K0 1/20 0.42
TAAR1 Q96RJ0 3/20 0.39
SMN1; SMN2 Q16637 1/20 0.39
AGXT P21549 2/20 0.38
MAOB P27338 2/20 0.38
MAOA P21397 1/20 0.38
CPA1 P15085 1/20 0.37
ESR1 P03372 1/20 0.35
ESR2 Q92731 1/20 0.35
PLA2G1B P04054 1/20 0.34
ATG4B Q9Y4P1 1/20 0.34
MIF P14174 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21538889 0.87 TRPA1 (0.40) TRPA1IDO1LOXL2TAAR1SMN1; SMN2
SCHEMBL16280734 0.80 TRPA1 (0.46) TRPA1IDO1LOXL2TAAR1SMN1; SMN2
SCHEMBL6444854 0.80 LOXL2 (0.43) TRPA1IDO1LOXL2TAAR1SMN1; SMN2
SCHEMBL6443722 0.80 LOXL2 (0.43) TRPA1IDO1LOXL2TAAR1SMN1; SMN2
SCHEMBL1061707 0.78 EPHX1 (0.48) TAAR1MAOBMAOA
SCHEMBL23368181 0.77 LOXL2 (0.45) TRPA1IDO1LOXL2TAAR1SMN1; SMN2
SCHEMBL8776657 0.77 TRPA1 (0.43) TRPA1IDO1LOXL2TAAR1SMN1; SMN2
SCHEMBL21075947 0.76 TAAR1 (0.45) IDO1TAAR1MAOBMIF
SCHEMBL31375797 0.74 CPA1 (0.47) TRPA1SMN1; SMN2CPA1
SCHEMBL21574645 0.73 TP53 (0.41) TAAR1ESR1ESR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3560920-A1 SECONDARY ALCOHOL QUINOLINYL MODULATORS OF ROR GAMMA T Janssen Pharmaceutica NV (BE) 2019-10-30 EP disclosed
EP-3057949-B1 SECONDARY ALCOHOL QUINOLINYL MODULATORS OF ROR GAMMA T JANSSEN PHARMACEUTICA NV (BE) 2019-06-05 EP disclosed
EP-2909192-B1 METHYLENE LINKED QUINOLINYL MODULATORS OF ROR-GAMMA-T JANSSEN PHARMACEUTICA NV (BE) 2017-05-17 EP disclosed