Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.33 |
| ▸ | TP53 | P04637 | 3/20 | 0.33 |
| ▸ | EPAS1 | Q99814 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | CES2 | O00748 | 1/20 | 0.33 |
| ▸ | APAF1 | O14727 | 1/20 | 0.33 |
| ▸ | TERT | O14746 | 1/20 | 0.33 |
| ▸ | EED | O75530 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6992256 | 0.79 | ALDH1A1 (0.42) | ALDH1A1HTTHIF1ATP53EPAS1 | |
| SCHEMBL8771832 | 0.78 | TP53 (0.33) | ALDH1A1HIF1ATP53EPAS1MEN1 | |
| SCHEMBL445935 | 0.78 | MALT1 (0.41) | MEN1KMT2ATDP1CES1L3MBTL1 | |
| SCHEMBL30279114 | 0.78 | MALT1 (0.41) | MEN1KMT2ATDP1CES1L3MBTL1 | |
| SCHEMBL8662369 | 0.78 | TDP2 (0.40) | ALDH1A1HIF1ATP53EPAS1MEN1 | |
| SCHEMBL31650524 | 0.78 | PBRM1 (0.53) | ALDH1A1LMNAMAPTKDM4EESR1 | |
| SCHEMBL8662092 | 0.78 | PBRM1 (0.53) | ALDH1A1LMNAMAPTKDM4EESR1 | |
| SCHEMBL6240700 | 0.78 | HSD17B10 (0.44) | ALDH1A1HTTHIF1ATP53EPAS1 | |
| SCHEMBL15716876 | 0.78 | MALT1 (0.41) | ALDH1A1MAPTPOLBCES1RXRA | |
| SCHEMBL2061344 | 0.75 | KDM4E (0.45) | ALDH1A1HTTMAPK1KDM4ECYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2684874-B1 | Fused bicyclic derivatives of 2,4-diaminopyrimidine as alk and C-met inhibitors | CEPHALON INC (US) | 2017-05-17 | — | — | EP | disclosed |