Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.59 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.38 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.38 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.38 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18858378 | 0.87 | ALDH1A1 (0.49) | ALDH1A1MAPTMEN1KMT2AKDM4E | |
| SCHEMBL14408833 | 0.77 | MEN1 (0.48) | ALDH1A1MAPTMEN1KMT2AKDM4E | |
| SCHEMBL10473274 | 0.76 | MEN1 (0.47) | ALDH1A1MAPTMEN1KMT2AKDM4E | |
| SCHEMBL17338584 | 0.74 | MAPT (0.46) | ALDH1A1MAPTMEN1KMT2AKDM4E | |
| SCHEMBL20618157 | 0.72 | MEN1 (0.49) | ALDH1A1MAPTMEN1KMT2AKDM4E | |
| SCHEMBL2705838 | 0.71 | MEN1 (0.55) | ALDH1A1MAPTMEN1KMT2AGAA | |
| SCHEMBL10908636 | 0.70 | ALDH1A1 (0.43) | ALDH1A1MEN1KMT2AHSD17B10L3MBTL1 | |
| SCHEMBL1832087 | 0.70 | ALDH1A1 (0.57) | ALDH1A1MAPTMEN1KMT2AHPGD | |
| SCHEMBL490810 | 0.70 | MAPT (0.70) | ALDH1A1MAPTMEN1KMT2AKDM4E | |
| SCHEMBL31460799 | 0.70 | MAPT (0.70) | ALDH1A1MAPTMEN1KMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170137419-A1 | DERIVATIVES OF 2H-PYRAZOLO[4,3-C]QUINOLIN-3(5H)-ONE AND USE THEREOF | INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE) (FR) | 2017-05-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170137419-A1 | DERIVATIVES OF 2H-PYRAZOLO[4,3-C]QUINOLIN-3(5H)-ONE AND USE THEREOF | CYP3A43, CYP3A5, CYP2D6 | ALDH1A1 286/4885MAPT 1476/4885MEN1 3002/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.