Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHB4 | P54760 | 1/20 | 0.39 |
| ▸ | KIT | P10721 | 2/20 | 0.38 |
| ▸ | AXL | P30530 | 1/20 | 0.35 |
| ▸ | MERTK | Q12866 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.33 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.33 |
| ▸ | FEN1 | P39748 | 1/20 | 0.33 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.33 |
| ▸ | EGFR | P00533 | 1/20 | 0.33 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.33 |
| ▸ | AURKA | O14965 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24391197 | 0.84 | KIT (0.39) | EPHB4KITAXLMERTKCYP3A4 | |
| SCHEMBL15334430 | 0.77 | KIT (0.53) | KITAXLMERTKTSHRKDM4E | |
| SCHEMBL24391199 | 0.72 | KIT (0.42) | KITALDH1A1MAPK14ALOX5APFEN1 | |
| SCHEMBL24391179 | 0.72 | GAA (0.40) | KITCYP3A4TSHRGAAALOX5AP | |
| SCHEMBL18861122 | 0.72 | KDR (0.45) | EPHB4CYP3A4KDM4ENPC1ALDH1A1 | |
| SCHEMBL18860442 | 0.71 | EPHB4 (0.42) | EPHB4KITAXLMERTKCYP3A4 | |
| SCHEMBL13385808 | 0.70 | TSHR (0.41) | KITCYP3A4TSHRKDM4ENPC1 | |
| SCHEMBL240923 | 0.70 | — | — | |
| SCHEMBL7607008 | 0.70 | ITGB2 (0.42) | KITCYP3A4TSHRKDM4EALDH1A1 | |
| SCHEMBL3529866 | 0.70 | KDR (0.62) | EPHB4KITAXLMAP4K4AURKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220002277-A1 | PYRIDONE DERIVATIVE HAVING TETRAHYDROPYRANYLMETHYL GROUP | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2022-01-06 | — | — | US | disclosed |
| US-11208403-B2 | Pyridone derivatives having tetrahydropyranylmethyl groups | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2021-12-28 | — | — | US | disclosed |
| EP-3168219-B1 | PYRIDONE DERIVATIVE HAVING TETRAHYDROPYRANYL METHYL GROUP | DAIICHI SANKYO CO LTD (JP) | 2021-03-31 | — | — | EP | disclosed |
| US-10442797-B2 | Pyridone derivatives having tetrahydropyranylmethyl groups | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2019-10-15 | — | — | US | disclosed |
| US-20180148436-A2 | PYRIDONE DERIVATIVES HAVING TETRAHYDROPYRANYLMETHYL GROUPS | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2018-05-31 | — | — | US | disclosed |
| US-20180148436-A2 | PYRIDONE DERIVATIVES HAVING TETRAHYDROPYRANYLMETHYL GROUPS | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2018-05-31 | — | — | US | disclosed |
| US-20170183329-A1 | PYRIDONE DERIVATIVE HAVING TETRAHYDROPYRANYLMETHYL GROUP | DAIICHI SANKYO CO LTD (JP) | 2017-06-29 | — | — | US | disclosed |
| US-20170183329-A1 | PYRIDONE DERIVATIVE HAVING TETRAHYDROPYRANYLMETHYL GROUP | DAIICHI SANKYO CO LTD (JP) | 2017-06-29 | — | — | US | disclosed |
| EP-3168219-A1 | PYRIDONE DERIVATIVE HAVING TETRAHYDROPYRANYL METHYL GROUP | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2017-05-17 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220002277-A1 | PYRIDONE DERIVATIVE HAVING TETRAHYDROPYRANYLMETHYL GROUP | AXL, TYRO3, LCK | EPHB4 897/4885KIT 1770/4885AXL 1/4885 |
| US-10442797-B2 | Pyridone derivatives having tetrahydropyranylmethyl groups | AXL, TYRO3, PDXK | EPHB4 641/4885KIT 1988/4885AXL 1/4885 |
| US-20170183329-A1 | PYRIDONE DERIVATIVE HAVING TETRAHYDROPYRANYLMETHYL GROUP | AXL, TYRO3, PDXK | EPHB4 751/4885KIT 1891/4885AXL 1/4885 |
| US-11208403-B2 | Pyridone derivatives having tetrahydropyranylmethyl groups | AXL, TYRO3, PDXK | EPHB4 641/4885KIT 1988/4885AXL 1/4885 |
| US-20180148436-A2 | PYRIDONE DERIVATIVES HAVING TETRAHYDROPYRANYLMETHYL GROUPS | AXL, TYRO3, PDXK | EPHB4 641/4885KIT 1988/4885AXL 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.