Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK2 | O96017 | 3/20 | 0.52 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.52 |
| ▸ | FYN | P06241 | 5/20 | 0.50 |
| ▸ | AXL | P30530 | 13/20 | 0.49 |
| ▸ | MERTK | Q12866 | 13/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18861126 | 0.93 | CHEK2 (0.52) | CHEK2CHEK1FYNAXLMERTK | |
| SCHEMBL18861081 | 0.89 | CHEK2 (0.55) | CHEK2CHEK1FYNAXLMERTK | |
| SCHEMBL18860989 | 0.87 | FYN (0.55) | CHEK2CHEK1FYNAXLMERTK | |
| SCHEMBL23158630 | 0.84 | CHEK2 (0.61) | CHEK2CHEK1FYNAXLMERTK | |
| SCHEMBL18860414 | 0.81 | CHEK2 (0.66) | CHEK2CHEK1FYN | |
| SCHEMBL18861171 | 0.80 | FYN (0.46) | CHEK2CHEK1FYNAXLMERTK | |
| SCHEMBL26946789 | 0.78 | FYN (0.46) | CHEK2CHEK1FYNAXLMERTK | |
| SCHEMBL19048389 | 0.78 | CHEK1 (0.53) | CHEK2CHEK1FYNAXLMERTK | |
| SCHEMBL18860437 | 0.77 | FYN (0.69) | CHEK2CHEK1FYN | |
| SCHEMBL23158768 | 0.76 | CHEK2 (0.55) | CHEK2CHEK1FYN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3168219-A1 | PYRIDONE DERIVATIVE HAVING TETRAHYDROPYRANYL METHYL GROUP | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2017-05-17 | — | — | EP | disclosed |