Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FYN | P06241 | 13/20 | 0.55 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.54 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.54 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.49 |
| ▸ | AXL | P30530 | 5/20 | 0.48 |
| ▸ | MERTK | Q12866 | 5/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18860959 | 0.87 | CHEK2 (0.52) | FYNCHEK1CHEK2AXLMERTK | |
| SCHEMBL26946789 | 0.87 | FYN (0.46) | FYNCHEK1CHEK2AXLMERTK | |
| SCHEMBL19048389 | 0.87 | CHEK1 (0.53) | FYNCHEK1CHEK2TGFBR1AXL | |
| SCHEMBL15334326 | 0.86 | FYN (0.60) | FYNCHEK1CHEK2TGFBR1 | |
| SCHEMBL29631737 | 0.86 | FYN (0.60) | FYNCHEK1CHEK2TGFBR1 | |
| SCHEMBL18860437 | 0.86 | FYN (0.69) | FYNCHEK1CHEK2TGFBR1 | |
| SCHEMBL18861171 | 0.85 | FYN (0.46) | FYNCHEK1CHEK2TGFBR1AXL | |
| SCHEMBL18861106 | 0.82 | FYN (0.61) | FYNCHEK1CHEK2TGFBR1 | |
| SCHEMBL29631642 | 0.81 | FYN (0.59) | FYNCHEK1CHEK2TGFBR1 | |
| SCHEMBL28343466 | 0.81 | FYN (0.59) | FYNCHEK1CHEK2TGFBR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3168219-B1 | PYRIDONE DERIVATIVE HAVING TETRAHYDROPYRANYL METHYL GROUP | DAIICHI SANKYO CO LTD (JP) | 2021-03-31 | — | — | EP | disclosed |
| EP-3168219-A1 | PYRIDONE DERIVATIVE HAVING TETRAHYDROPYRANYL METHYL GROUP | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2017-05-17 | — | — | EP | disclosed |