Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.36 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.36 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.36 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.36 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.36 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.33 |
| ▸ | BTK | Q06187 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12371005 | 0.84 | HDAC8 (0.37) | CYP3A4CYP2D6PSEN1PSEN2APH1B | |
| SCHEMBL30147514 | 0.80 | SYK (0.32) | — | |
| SCHEMBL18839235 | 0.80 | SYK (0.32) | — | |
| SCHEMBL3256436 | 0.73 | ROCK1 (0.37) | CYP3A4CYP2D6PSEN1PSEN2APH1B | |
| SCHEMBL24258354 | 0.72 | — | — | |
| SCHEMBL16289411 | 0.70 | — | — | |
| SCHEMBL29503544 | 0.70 | ALDH1A1 (0.39) | CYP3A4CYP2D6PSEN1PSEN2APH1B | |
| SCHEMBL12093203 | 0.70 | LOXL2 (0.43) | CYP3A4 | |
| SCHEMBL1655827 | 0.70 | ALDH1A1 (0.39) | CYP3A4CYP2D6PSEN1PSEN2APH1B | |
| SCHEMBL14723341 | 0.69 | BTK (0.35) | BTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017080979-A1 | DIHYDROIMIDAZOPYRAZINONE DERIVATIVES USEFUL IN THE TREATMENT OF CANCER | ASTRAZENECA AB (SE) | 2017-05-18 | — | — | WO | disclosed |