Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 6/20 | 0.77 |
| ▸ | NPC1 | O15118 | 1/20 | 0.69 |
| ▸ | CCR3 | P51677 | 3/20 | 0.63 |
| ▸ | MEN1 | O00255 | 2/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1575818 | 0.89 | CCR3 (0.62) | FAAHNPC1CCR3MEN1KMT2A | |
| SCHEMBL3600315 | 0.87 | FAAH (1.00) | FAAHCCR3MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL3594301 | 0.86 | FAAH (1.00) | FAAHCCR3MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL17742829 | 0.86 | FAAH (0.77) | FAAHNPC1CCR3MEN1KMT2A | |
| SCHEMBL830207 | 0.82 | FAAH (0.74) | FAAHCCR3MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL5358819 | 0.81 | FAAH (0.85) | FAAHCCR3MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL13841263 | 0.80 | LMNA (0.81) | NPC1MEN1KMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL1575084 | 0.80 | FAAH (0.60) | FAAHCCR3MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL23573500 | 0.79 | NPC1 (0.70) | NPC1MEN1KMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL13234936 | 0.79 | FAAH (0.82) | FAAHNPC1MEN1KMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017083242-A1 | INHIBITORS OF SUPPRESSION OF TUMORIGENCITY 2 (ST2) AND METHODS USING THE SAME | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2017-05-18 | — | — | WO | disclosed |