SCHEMBL18862050

CCOC(=O)[C@H](C)NC(=O)[C@H](CC1=CNCN1)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC1=CNCN1)NC(=O)[C@@H](N)Cc1c[nH]c2ccccc12

nearest known ligand 0.51

Predicted protein targets (top 5)

	gene	UniProt	supporting neighbours	confidence
▸	IL1RN	P18510	17/20	0.51

▸	ERAP2	Q6P179	17/20	0.51

▸	ERAP1	Q9NZ08	9/20	0.49

▸	OPRM1	P35372	1/20	0.46

▸	OPRD1	P41143	1/20	0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL18862051	0.91	ERAP2 (0.54)	IL1RNERAP2ERAP1OPRM1OPRD1
SCHEMBL18862460	0.91	ERAP2 (0.54)	IL1RNERAP2ERAP1OPRM1OPRD1
SCHEMBL18862071	0.91	ERAP2 (0.54)	IL1RNERAP2ERAP1OPRM1OPRD1
SCHEMBL18862054	0.83	GHSR (0.58)	—
SCHEMBL18862045	0.83	GHSR (0.58)	—
SCHEMBL30169818	0.80	ERAP2 (0.64)	IL1RNERAP2ERAP1
SCHEMBL30051718	0.80	ERAP2 (0.64)	IL1RNERAP2ERAP1
SCHEMBL11664273	0.78	IL1RN (0.67)	IL1RNERAP2ERAP1
SCHEMBL29538468	0.78	ERAP2 (0.69)	IL1RNERAP2ERAP1
SCHEMBL29350923	0.78	IL1RN (0.67)	IL1RNERAP2ERAP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
US-20170137801-A1	TISSUE-SPECIFIC GENOME ENGINEERING USING CRISPR-CAS9	THE REGENTS OF THE UNIVERSITY OF CALIFORNIA	2017-05-18	—	—	US	disclosed