SCHEMBL18862075

CC(C)CC(NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](N)Cc1c[nH]c2ccccc12)C(=O)N[C@@H](C)C(N)=O

nearest known ligand 0.60

Predicted protein targets (top 2)

	gene	UniProt	supporting neighbours	confidence
▸	NPBWR1	P48145	17/20	0.60

▸	ERAP2	Q6P179	1/20	0.58

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL18854324	0.94	ERAP2 (0.58)	NPBWR1ERAP2
SCHEMBL18862079	0.93	GHSR (0.62)	—
SCHEMBL31256796	0.92	NPBWR1 (0.59)	NPBWR1
SCHEMBL29723828	0.91	NPBWR1 (0.60)	NPBWR1
SCHEMBL31177122	0.91	NPBWR1 (0.60)	NPBWR1
SCHEMBL31177131	0.91	NPBWR1 (0.60)	NPBWR1
SCHEMBL30789083	0.90	ERAP2 (0.62)	NPBWR1ERAP2
SCHEMBL30376277	0.90	NPBWR1 (0.60)	NPBWR1
SCHEMBL31177126	0.89	NPBWR1 (0.59)	NPBWR1
SCHEMBL31177125	0.89	NPBWR1 (0.59)	NPBWR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
US-20170137801-A1	TISSUE-SPECIFIC GENOME ENGINEERING USING CRISPR-CAS9	THE REGENTS OF THE UNIVERSITY OF CALIFORNIA	2017-05-18	—	—	US	disclosed