Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 18/20 | 0.79 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.54 |
| ▸ | KDR | P35968 | 1/20 | 0.54 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.54 |
| ▸ | ERBB2 | P04626 | 3/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18862908 | 0.90 | EGFR (0.68) | EGFREPHA2KDREPHB4ERBB2 | |
| SCHEMBL20619958 | 0.88 | EGFR (0.79) | EGFREPHA2KDREPHB4ERBB2 | |
| SCHEMBL15090523 | 0.88 | EGFR (1.00) | EGFRKDREPHB4ERBB2 | |
| SCHEMBL15105017 | 0.87 | EGFR (0.86) | EGFRERBB2 | |
| SCHEMBL15090516 | 0.87 | EGFR (0.86) | EGFRERBB2 | |
| SCHEMBL255527 | 0.87 | EGFR (0.72) | EGFREPHA2KDREPHB4ERBB2 | |
| SCHEMBL15090527 | 0.86 | EGFR (0.84) | EGFRERBB2 | |
| SCHEMBL15090569 | 0.86 | EGFR (0.84) | EGFRERBB2 | |
| SCHEMBL21761244 | 0.86 | EGFR (0.63) | EGFREPHA2KDREPHB4ERBB2 | |
| SCHEMBL18633092 | 0.86 | EGFR (0.81) | EGFREPHA2KDREPHB4ERBB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2716633-B1 | QUINAZOLINE DERIVATIVE AS TYROSINE-KINASE INHIBITOR, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF | XUANZHU PHARMA CO LTD (CN) | 2017-05-17 | — | — | EP | disclosed |