Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 19/20 | 0.81 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.55 |
| ▸ | KDR | P35968 | 1/20 | 0.55 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.55 |
| ▸ | ERBB2 | P04626 | 3/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL255508 | 0.89 | EGFR (1.00) | EGFRKDREPHB4ERBB2 | |
| SCHEMBL15106899 | 0.88 | EGFR (0.74) | EGFREPHA2KDREPHB4ERBB2 | |
| SCHEMBL15090643 | 0.86 | EGFR (0.72) | EGFREPHA2KDREPHB4 | |
| SCHEMBL18862908 | 0.86 | EGFR (0.68) | EGFREPHA2KDREPHB4ERBB2 | |
| SCHEMBL18862743 | 0.86 | EGFR (0.79) | EGFREPHA2KDREPHB4ERBB2 | |
| SCHEMBL21761244 | 0.82 | EGFR (0.63) | EGFREPHA2KDREPHB4ERBB2 | |
| SCHEMBL21761372 | 0.81 | EGFR (0.69) | EGFRKDREPHB4ERBB2 | |
| SCHEMBL21761309 | 0.80 | EGFR (0.66) | EGFREPHA2KDREPHB4ERBB2 | |
| SCHEMBL18862756 | 0.79 | EGFR (0.58) | EGFREPHA2KDREPHB4ERBB2 | |
| SCHEMBL18632967 | 0.78 | FBP1 (0.76) | EGFRKDREPHB4ERBB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2612860-B1 | QUINAZOLINE DERIVATIVES SUBSTITUTED BY ANILINE, PREPARATION METHOD AND USE THEREOF | XUANZHU PHARMA CO LTD (CN) | 2017-03-15 | — | — | EP | disclosed |