Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 17/20 | 0.68 |
| ▸ | ERBB4 | Q15303 | 2/20 | 0.54 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.52 |
| ▸ | KDR | P35968 | 1/20 | 0.52 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.52 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18862756 | 0.92 | EGFR (0.58) | EGFRERBB4EPHA2KDREPHB4 | |
| SCHEMBL18862743 | 0.90 | EGFR (0.79) | EGFREPHA2KDREPHB4ERBB2 | |
| SCHEMBL15090536 | 0.88 | EGFR (0.87) | EGFRERBB4KDREPHB4ERBB2 | |
| SCHEMBL15106807 | 0.87 | EGFR (0.62) | EGFREPHA2KDREPHB4ERBB2 | |
| SCHEMBL18633092 | 0.86 | EGFR (0.81) | EGFREPHA2KDREPHB4ERBB2 | |
| SCHEMBL15090803 | 0.85 | EGFR (0.61) | EGFREPHA2KDREPHB4 | |
| SCHEMBL15090494 | 0.84 | EGFR (0.81) | EGFRERBB4KDREPHB4ERBB2 | |
| SCHEMBL18595943 | 0.83 | EGFR (0.76) | EGFRERBB4ERBB2 | |
| SCHEMBL15106854 | 0.83 | EGFR (0.58) | EGFREPHA2KDREPHB4ERBB2 | |
| SCHEMBL21761244 | 0.83 | EGFR (0.63) | EGFRERBB4EPHA2KDREPHB4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2716633-B1 | QUINAZOLINE DERIVATIVE AS TYROSINE-KINASE INHIBITOR, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF | XUANZHU PHARMA CO LTD (CN) | 2017-05-17 | — | — | EP | disclosed |