Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB2 | P05107 | 19/20 | 0.69 |
| ▸ | ICAM1 | P05362 | 19/20 | 0.69 |
| ▸ | ITGAL | P20701 | 19/20 | 0.69 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13894063 | 0.91 | ITGB2 (0.70) | ITGB2ICAM1ITGALHDAC6CYP2C9 | |
| SCHEMBL13665300 | 0.89 | ITGB2 (0.75) | ITGB2ICAM1ITGALCYP2C9 | |
| SCHEMBL18868483 | 0.88 | ITGB2 (0.74) | ITGB2ICAM1ITGALCYP2C9 | |
| SCHEMBL18868611 | 0.88 | ITGB2 (0.65) | ITGB2ICAM1ITGALHDAC6CYP2C9 | |
| SCHEMBL23176450 | 0.88 | ITGB2 (0.56) | ITGB2ICAM1ITGALHDAC6CYP2C9 | |
| SCHEMBL13894108 | 0.85 | ITGB2 (0.65) | ITGB2ICAM1ITGALHDAC6CYP2C9 | |
| SCHEMBL22296836 | 0.83 | NPC1 (0.53) | ITGB2ICAM1ITGAL | |
| SCHEMBL18868522 | 0.83 | ITGB2 (0.70) | ITGB2ICAM1ITGALCYP2C9 | |
| SCHEMBL17991448 | 0.83 | ITGB2 (0.74) | ITGB2ICAM1ITGALCYP2C9 | |
| SCHEMBL18868524 | 0.82 | ITGB2 (0.53) | ITGB2ICAM1ITGALHDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3797775-A1 | COMPOSITIONS AND METHODS FOR TREATMENT OF DIABETIC RETINOPATHY | Novartis AG (CH) | 2021-03-31 | — | — | EP | disclosed |
| EP-3167886-B1 | COMPOSITIONS AND METHODS FOR TREATMENT OF MACULAR EDEMA | NOVARTIS AG (CH) | 2020-08-05 | — | — | EP | disclosed |
| EP-3167886-A1 | COMPOSITIONS AND METHODS FOR TREATMENT OF MACULAR EDEMA | SARcode Bioscience Inc. (US) | 2017-05-17 | — | — | EP | disclosed |