Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | PIN1 | Q13526 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.37 |
| ▸ | SYK | P43405 | 3/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | EGFR | P00533 | 5/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | ITK | Q08881 | 1/20 | 0.34 |
| ▸ | ESR1 | P03372 | 1/20 | 0.33 |
| ▸ | KDR | P35968 | 1/20 | 0.33 |
| ▸ | CDK4 | P11802 | 1/20 | 0.33 |
| ▸ | CDK2 | P24941 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16264855 | 0.82 | SYK (0.43) | MEN1KMT2AKDM4ENFKB1SYK | |
| SCHEMBL16246107 | 0.82 | MEN1 (0.41) | MEN1KMT2APIN1KDM4ENFKB1 | |
| SCHEMBL18869373 | 0.80 | SYK (0.56) | MEN1KMT2AKDM4ENFKB1SYK | |
| SCHEMBL18869076 | 0.79 | KDM4E (0.39) | MEN1KMT2APIN1KDM4ENFKB1 | |
| SCHEMBL18869322 | 0.78 | P2RX3 (0.43) | KDM4ESYKMAPTLMNA | |
| SCHEMBL18869082 | 0.78 | RAB9A (0.49) | MEN1KMT2APIN1MAPTEGFR | |
| SCHEMBL16245606 | 0.77 | PIN1 (0.64) | MEN1KMT2APIN1MAPTEGFR | |
| SCHEMBL656104 | 0.69 | SYK (0.59) | MEN1KMT2AKDM4ENFKB1SYK | |
| SCHEMBL18869411 | 0.69 | STK17B (0.48) | SYKMAPTGAA | |
| SCHEMBL16012041 | 0.68 | SYK (0.44) | MEN1KMT2AKDM4ENFKB1SYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2994471-B1 | MACROCYCLES AS KINASE INHIBITORS | MERCK PATENT GMBH (DE) | 2017-05-17 | — | — | EP | disclosed |