Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | TSHR | P16473 | 4/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | UCHL1 | P09936 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28780110 | 0.81 | ALDH1A1 (0.41) | ALDH1A1TSHRMEN1KMT2AL3MBTL1 | |
| SCHEMBL3644512 | 0.79 | ALDH1A1 (0.39) | ALDH1A1TSHRMEN1KMT2AL3MBTL1 | |
| SCHEMBL27870909 | 0.79 | ALDH1A1 (0.39) | ALDH1A1TSHRMEN1KMT2AL3MBTL1 | |
| SCHEMBL693163 | 0.77 | MAPT (0.50) | ALDH1A1KMT2AL3MBTL1NPC1MAPT | |
| SCHEMBL25238658 | 0.73 | HSP90AA1 (0.52) | ALDH1A1TSHRMEN1KMT2AL3MBTL1 | |
| SCHEMBL7469150 | 0.72 | RIPK1 (0.63) | ALDH1A1TSHRMEN1KMT2AL3MBTL1 | |
| SCHEMBL17114341 | 0.72 | RIPK1 (0.63) | ALDH1A1TSHRMEN1KMT2AL3MBTL1 | |
| SCHEMBL24365782 | 0.72 | RIPK1 (0.63) | ALDH1A1TSHRMEN1KMT2AL3MBTL1 | |
| Water SCHEMBL28772891 | 0.72 | RIPK1 (0.46) | ALDH1A1TSHRNPC1LMNAHSD17B10 | |
| SCHEMBL28039237 | 0.72 | HSD17B10 (0.48) | ALDH1A1MEN1KMT2ANPC1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2401281-A1 | PYRIMIDOPYRIMIDOINDAZOLE DERIVATIVE | MSD K.K. (JP) | 2012-01-04 | — | — | EP | disclosed |
| WO-2010098367-A1 | PYRIMIDOPYRIMIDOINDAZOLE DERIVATIVE | BANYU PHARMACEUTICAL CO.,LTD. (JP) | 2010-09-02 | — | — | WO | disclosed |