Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.32 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.32 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.32 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.32 |
| ▸ | GAA | P10253 | 2/20 | 0.32 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.32 |
| ▸ | KLK7 | P49862 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL567269 | 0.79 | — | — | |
| SCHEMBL17988329 | 0.73 | HSD17B10 (0.52) | ALDH1A1L3MBTL1HSD17B10HPGDTSHR | |
| SCHEMBL568110 | 0.70 | CHRNA4 (0.34) | CHRNA4 | |
| SCHEMBL3439381 | 0.70 | CHRNA4 (0.34) | CHRNA4 | |
| SCHEMBL20424521 | 0.67 | GAA (0.32) | ALDH1A1GAACYP1A2CYP2C19 | |
| SCHEMBL20424523 | 0.67 | GAA (0.32) | ALDH1A1GAACYP1A2CYP2C19 | |
| SCHEMBL21259828 | 0.67 | GABRA1 (0.35) | GAA | |
| SCHEMBL21248346 | 0.67 | GABRA1 (0.35) | GAA | |
| SCHEMBL12450721 | 0.67 | USP2 (0.36) | ALDH1A1TSHRGAACYP2C19 | |
| SCHEMBL21259812 | 0.65 | ALDH1A1 (0.47) | ALDH1A1HPGDPOLBCHRNB2CHRNB4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11040960-B2 | Inhibitors of CXCR2 | CHEMOCENTRYX, INC. (US) | 2021-06-22 | — | — | US | disclosed |
| EP-3377059-B1 | INHIBITORS OF CXCR2 | CHEMOCENTRYX INC (US) | 2020-10-21 | — | — | EP | disclosed |
| US-20200140418-A1 | INHIBITORS OF CXCR2 | CHEMOCENTRYX, INC. | 2020-05-07 | — | — | US | disclosed |
| US-10370363-B2 | Inhibitors of CXCR2 | CHEMOCENTRYX, INC. (US) | 2019-08-06 | — | — | US | disclosed |
| US-20180170916-A1 | INHIBITORS OF CXCR2 | CHEMOCENTRYX, INC. | 2018-06-21 | — | — | US | disclosed |
| US-20180170916-A1 | INHIBITORS OF CXCR2 | CHEMOCENTRYX, INC. | 2018-06-21 | — | — | US | disclosed |
| US-9809581-B2 | Inhibitors of CXCR2 | CHEMOCENTRYX, INC. (US) | 2017-11-07 | — | — | US | disclosed |
| US-9809581-B2 | Inhibitors of CXCR2 | CHEMOCENTRYX, INC. (US) | 2017-11-07 | — | — | US | disclosed |
| US-20170144996-A1 | INHIBITORS OF CXCR2 | CHEMOCENTRYX, INC. | 2017-05-25 | — | — | US | disclosed |
| US-20170144996-A1 | INHIBITORS OF CXCR2 | CHEMOCENTRYX, INC. | 2017-05-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170144996-A1 | INHIBITORS OF CXCR2 | CXCR2, CXCR3, CXCR1 | ALDH1A1 4057/4885L3MBTL1 2913/4885HSD17B10 3396/4885 |
| US-20200140418-A1 | INHIBITORS OF CXCR2 | CXCR2, CXCR3, CXCR1 | ALDH1A1 4057/4885L3MBTL1 2913/4885HSD17B10 3396/4885 |
| US-10370363-B2 | Inhibitors of CXCR2 | CXCR2, CXCR3, CXCR1 | ALDH1A1 4057/4885L3MBTL1 2913/4885HSD17B10 3396/4885 |
| US-11040960-B2 | Inhibitors of CXCR2 | CXCR2, CXCR3, CXCR1 | ALDH1A1 4057/4885L3MBTL1 2913/4885HSD17B10 3396/4885 |
| US-20180170916-A1 | INHIBITORS OF CXCR2 | CXCR2, CXCR3, CXCR1 | ALDH1A1 4057/4885L3MBTL1 2913/4885HSD17B10 3398/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.