⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31006320 | 0.69 | — | — | |
| SCHEMBL14596382 | 0.69 | — | — | |
| SCHEMBL31563006 | 0.58 | ENO1 (0.31) | — | |
| SCHEMBL472598 | 0.55 | — | — | |
| SCHEMBL16241627 | 0.54 | ADRA2C (0.30) | — | |
| SCHEMBL16253382 | 0.54 | ADRA2C (0.30) | — | |
| SCHEMBL237156 | 0.54 | — | — | |
| SCHEMBL10746690 | 0.50 | ADRA2C (0.56) | — | |
| SCHEMBL223179 | 0.50 | ADRA2C (0.56) | — | |
| Symclosene SCHEMBL28549965 | 0.49 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210363142-A1 | AGONISTS OF THE APELIN RECEPTOR AND METHODS OF USE THEREOF | Sanford Burnham Prebys Medical Discovery Institute | 2021-11-25 | — | — | US | disclosed |
| US-10370379-B2 | Compounds and compositions useful for treating disorders related to NTRK | BLUEPRINT MEDICINES CORPORATION (US) | 2019-08-06 | — | — | US | disclosed |
| US-10280163-B2 | 5 or 8-substituted imidazo[1, 5-a] pyridines as indoleamine and/or tryptophane 2, 3-dioxygenases | BEIGENE, LTD. (KY) | 2019-05-07 | — | — | US | disclosed |
| US-20180118665-A1 | FTO Inhibitors | NATIONAL INSTITUTE OF BIOLOGICAL SCIENCES, BEIJING (CN) | 2018-05-03 | — | — | US | disclosed |
| US-20180072716-A1 | NOVEL 5 OR 8-SUBSTITUTED IMIDAZO[1, 5-a] PYRIDINES AS INDOLEAMINE AND/OR TRYPTOPHANE 2, 3-DIOXYGENASES | BEONE MEDICINES I GMBH (CH) | 2018-03-15 | — | — | US | disclosed |
| US-20170145018-A1 | COMPOUNDS AND COMPOSITIONS USEFUL FOR TREATING DISORDERS RELATED TO NTRK | BLUEPRINT MEDICINES CORPORATION | 2017-05-25 | — | — | US | disclosed |