Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LATS1 | O95835 | 7/20 | 0.42 |
| ▸ | LATS2 | Q9NRM7 | 6/20 | 0.42 |
| ▸ | AOC1 | P19801 | 2/20 | 0.42 |
| ▸ | AOC3 | Q16853 | 2/20 | 0.42 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.41 |
| ▸ | KDM4A | O75164 | 1/20 | 0.41 |
| ▸ | KDM4B | O94953 | 1/20 | 0.41 |
| ▸ | KDM5C | P41229 | 1/20 | 0.41 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.41 |
| ▸ | KDM3A | Q9Y4C1 | 1/20 | 0.41 |
| ▸ | CHUK | O15111 | 1/20 | 0.39 |
| ▸ | HTR1A | P08908 | 2/20 | 0.38 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.38 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.38 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.38 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18878996 | 0.85 | AOC1 (0.42) | AOC1AOC3KDM4CHTR1AADRA1D | |
| SCHEMBL3722002 | 0.81 | CA12 (0.44) | LATS1LATS2KDM4CKDM4AKDM4B | |
| SCHEMBL31375766 | 0.78 | ALK (0.54) | ADRA1AEGFR | |
| SCHEMBL4500702 | 0.76 | HTR1A (0.63) | HTR1AADRA1DADRA1AADRA1BEGFR | |
| SCHEMBL20278469 | 0.76 | KDM4E (0.43) | AOC1AOC3KDM4CHTR1AADRA1D | |
| Hydrochloric Acid SCHEMBL1208911 | 0.74 | HTR1A (0.61) | HTR1AADRA1DADRA1AADRA1BEGFR | |
| Hydrochloric Acid SCHEMBL29043209 | 0.74 | HTR1A (0.61) | HTR1AADRA1DADRA1AADRA1BEGFR | |
| SCHEMBL8277148 | 0.74 | CCR1 (0.46) | LATS1LATS2KDM4CKDM4AKDM4B | |
| SCHEMBL12653338 | 0.73 | TERT (0.50) | LATS1LATS2 | |
| SCHEMBL4251625 | 0.73 | MAPK10 (0.53) | HTR1AADRA1DADRA1AADRA1BPLK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170145009-A1 | HETEROCYCLIC COMPOUNDS THAT INHIBIT THE KINASE ACTIVITY OF MNK USEFUL FOR TREATING VARIOUS CANCERS | EFFECTOR THERAPEUTICS, INC. | 2017-05-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170145009-A1 | HETEROCYCLIC COMPOUNDS THAT INHIBIT THE KINASE ACTIVITY OF MNK USEFUL FOR TREATING VARIOUS CANCERS | MAP3K9, MAP3K19, MAP3K20 | LATS1 897/4885LATS2 884/4885AOC1 3929/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.